Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study

Gallardo Blanco, Hugo Leonid y Villarreal Pérez, Jesús Zacarías y Cerda Flores, Ricardo Martín y Figueroa, Andres y Sánchez Domínguez, Celia Nohemí y Gutiérrez Valverde, Juana Mercedes y Torres Muñoz, Iris Carmen y Lavalle González, Fernando Javier y Gallegos Cabriales, Esther Carlota y Martínez Garza, Laura Elia (2016) Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study. Experimental and Therapeutic Medicine, 13 (2). pp. 523-529. ISSN 1792-0981

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URL o página oficial: http://doi.org/10.3892/etm.2016.3990

Resumen

Abstract. The aim of the present study was to investigate whether genetic markers considered risk factors for metabolic syndromes, including dyslipidemia, obesity and type 2 diabetes mellitus (T2DM), can be applied to a Northeastern Mexican population. A total of 37 families were analyzed for 63 single nucleotide polymorphisms (SNPs), and the age, body mass index (BMI), glucose tolerance values and blood lipid levels, including those of cholesterol, low-density lipoprotein (LDL), very LDL (VLDL), high-density lipoprotein (HDL) and triglycerides were evaluated. Three genetic markers previously associated with metabolic syndromes were identified in the sample population, including KCNJ11, TCF7L2 and HNF4A. The KCNJ11 SNP rs5210 was associated with T2DM, the TCF7L2 SNP rs11196175 was associated with BMI and cholesterol and LDL levels, the TCF7L2 SNP rs12255372 was associated with BMI and HDL, VLDL and triglyceride levels, and the HNF4A SNP rs1885088 was associated with LDL levels (P<0.05).

Tipo de elemento: Article
Palabras claves no controlados: Type 2 diabetes, Association, High-density lipoprotein, Low-density lipoprotein, Cholesterol, Body mass index, Linkage disequilibrium, KCNJ11, TCF7L2, HNF4A
Materias: R Medicina > R Medicina en General
Divisiones: Medicina
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
Gallardo Blanco, Hugo LeonidNO ESPECIFICADONO ESPECIFICADO
Villarreal Pérez, Jesús ZacaríasNO ESPECIFICADONO ESPECIFICADO
Cerda Flores, Ricardo MartínNO ESPECIFICADONO ESPECIFICADO
Figueroa, AndresNO ESPECIFICADONO ESPECIFICADO
Sánchez Domínguez, Celia NohemíNO ESPECIFICADONO ESPECIFICADO
Gutiérrez Valverde, Juana MercedesNO ESPECIFICADONO ESPECIFICADO
Torres Muñoz, Iris CarmenNO ESPECIFICADONO ESPECIFICADO
Lavalle González, Fernando Javierdrfernandolavalle@hotmail.comNO ESPECIFICADO
Gallegos Cabriales, Esther Carlotaesther.gallegoscb@uanl.edu.mxorcid.org/0000-0003-3619-2596
Martínez Garza, Laura EliaNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 18 Mar 2020 19:23
Última modificación: 05 Mar 2024 15:36
URI: http://eprints.uanl.mx/id/eprint/18143

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