Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia
Jaime Pérez, José Carlos y Guerra Leal, Liliana Nataly y Cantú Rodríguez, Olga Graciela y Gómez Almaguer, David (2016) Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia. Revista Brasileira de Hematologia e Hemoterapia, 39 (1). pp. 57-59. ISSN 15168484
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Resumen
Aplastic anemia (AA) is a rare disorder characterized by suppression of bone marrow function. It can develop as the result of congenital marrow disease and chemical exposure; however, most cases are idiopathic.1 Treatment with immunosuppressive therapy (IST) for patients who do not have an human leukocyte antigen (HLA)-compatible donor relies on the evidence that a deregulated immune system drives T lymphocytes to cytokine-mediated destruction of their own hematopoietic stem cells.1 The majority of these patients respond well to up-front administration of IST, including antithymocyte globulin (ATG) and cyclosporine (CsA), which is successful in around 80%.2 Unfortunately, ATG and CsA can lead to clonal disorders, in particular myelodysplastic syndrome (MDS) and paroxysmal nocturnal hemoglobinuria
Tipo de elemento: | Article | |||||||||||||||
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Materias: | R Medicina > R Medicina en General | |||||||||||||||
Divisiones: | Medicina | |||||||||||||||
Usuario depositante: | Editor Repositorio | |||||||||||||||
Creadores: |
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Fecha del depósito: | 10 Mar 2020 14:54 | |||||||||||||||
Última modificación: | 10 Mar 2020 14:54 | |||||||||||||||
URI: | http://eprints.uanl.mx/id/eprint/18224 |
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