Microglia activation due to obesity programs metabolic failure leading to type two diabetes

Maldonado Ruiz, R y Montalvo Martínez, Larisa Jajaira y Fuentes Mera, Lizeth y Camacho, Alberto (2017) Microglia activation due to obesity programs metabolic failure leading to type two diabetes. Nutrition & Diabetes, 7 (3). pp. 1-9. ISSN 2044-4052

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URL o página oficial: http://doi.org/10.1038/nutd.2017.10

Resumen

Obesity is an energy metabolism disorder that increases susceptibility to the development of metabolic diseases. Recently, it has been described that obese subjects have a phenotype of chronic inflammation in organs that are metabolically relevant for glucose homeostasis and energy. Altered expression of immune system molecules such as interleukins IL-1, IL-6, IL-18, tumor necrosis factor alpha (TNF-α), serum amyloid A (SAA), and plasminogen activator inhibitor-1 (PAI-1), among others, has been associated with the development of chronic inflammation in obesity. Chronic inflammation modulates the development of metabolic-related comorbidities like metabolic syndrome (insulin resistance, glucose tolerance, hypertension and hyperlipidemia). Recent evidence suggests that microglia activation in the central nervous system (CNS) is a priority in the deregulation of energy homeostasis and promotes increased glucose levels. This review will cover the most significant advances that explore the molecular signals during microglia activation and inflammatory stage in the brain in the context of obesity, and its influence on the development of metabolic syndrome and type two diabetes.

Tipo de elemento: Article
Materias: R Medicina > R Medicina en General
R Medicina > RC Medicina Interna, Psiquiatría, Neurología
Divisiones: Medicina
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
Maldonado Ruiz, RNO ESPECIFICADONO ESPECIFICADO
Montalvo Martínez, Larisa JajairaNO ESPECIFICADONO ESPECIFICADO
Fuentes Mera, LizethNO ESPECIFICADONO ESPECIFICADO
Camacho, AlbertoNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 26 Feb 2020 18:26
Última modificación: 26 Mayo 2020 20:52
URI: http://eprints.uanl.mx/id/eprint/18259

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