Recent rapid rise of a permethrin knock down resistance allele in Aedes aegypti in México.

Ponce García, Gustavo y Flores Suárez, Adriana Elizabeth y Fernández Salas, Ildefonso y Saavedra Rodríguez, Karla Lizet y Reyes Solis, Guadalupe del Carmen y Lozano Fuentes, Saúl y Bond Compeán, Juan Guillermo y Casas Martínez, Mauricio y Ramsey, Janine M. y García Rejón, Julián Everardo y Domínguez Galera, Marco Antonio y Ranson, Hilary y Hemingway, Janet y Elsen, Lars y Black, William C. (2009) Recent rapid rise of a permethrin knock down resistance allele in Aedes aegypti in México. PLoS biology, 3 (10). pp. 1-10. ISSN 1545-7885

[img]
Vista previa
Texto
Recent_rapid_rise_of_a_permethrin_knock_down_resistance_allele_in_Aedes_aegypti_in_Mexico.pdf - Versión Aceptada
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (347kB) | Vista previa

Resumen

Pyrethroid insecticides prolong the opening of voltage-dependent sodium channels in insect nerves to produce instant paralysis and “knock-down.” Many insects have evolved knock-down resistance through nonsynonymous mutations that reduce pyrethroid binding in the channels. In 2006 we discovered one such mutation in the arbovirus mosquito vector Aedes aegypti, called Ile1,016, that confers very high knockdown resistance to the pyrethroid insecticide permethrin in mosquitoes homozygous for this mutation. We examined collections of Ae. aegypti from México during 1996–2009 and found that the overall Ile1,016 frequency increased from <0.1% in 1996–2000, to 2%–5% in 2003–2006, to 38.3%–88.3% in 2007–2009 depending upon collection location. We also demonstrate a strong linear relationship between the frequency of Ile1,016 homozygotes and knockdown rate in bioassays and speculate that widespread use of permethrin-based insecticides in México may be impacting the frequency of Ile1,016. Such a rapid increase is predicted by a simple model of positive directional selection acting on a recessive allele. Unfortunately this model also predicts rapid fixation of Ile1,016 unless there is a negative fitness associated with Ile1,016 in the absence of permethrin and if insecticidal pressure can be reduced.

Tipo de elemento: Article
Materias: ?? QH301 ??
?? QH426 ??
Divisiones: Ciencias Biológicas
Usuario depositante: Admin Eprints
Creadores:
CreadorEmailORCID
Ponce García, GustavoNO ESPECIFICADONO ESPECIFICADO
Flores Suárez, Adriana ElizabethNO ESPECIFICADONO ESPECIFICADO
Fernández Salas, Ildefonsoifernand1@hotmail.comNO ESPECIFICADO
Saavedra Rodríguez, Karla LizetNO ESPECIFICADONO ESPECIFICADO
Reyes Solis, Guadalupe del CarmenNO ESPECIFICADONO ESPECIFICADO
Lozano Fuentes, SaúlNO ESPECIFICADONO ESPECIFICADO
Bond Compeán, Juan GuillermoNO ESPECIFICADONO ESPECIFICADO
Casas Martínez, MauricioNO ESPECIFICADONO ESPECIFICADO
Ramsey, Janine M.NO ESPECIFICADONO ESPECIFICADO
García Rejón, Julián EverardoNO ESPECIFICADONO ESPECIFICADO
Domínguez Galera, Marco AntonioNO ESPECIFICADONO ESPECIFICADO
Ranson, HilaryNO ESPECIFICADONO ESPECIFICADO
Hemingway, JanetNO ESPECIFICADONO ESPECIFICADO
Elsen, LarsNO ESPECIFICADONO ESPECIFICADO
Black, William C.NO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 28 Ene 2011 19:38
Última modificación: 17 Feb 2016 16:35
URI: http://eprints.uanl.mx/id/eprint/2003

Actions (login required)

Ver elemento Ver elemento

Downloads

Downloads per month over past year