Increased cerebrospinal fluid levels of cytokines monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β) in patients with amyotrophic lateral sclerosis

Martínez, H.R. y Escamilla Ocañas, C.E. y Camara Lemarroy, C.R. y González Garza, M.T. y Moreno Cuevas, J.E. y García Sarreón, M.A. (2020) Increased cerebrospinal fluid levels of cytokines monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β) in patients with amyotrophic lateral sclerosis. Neurología (English Edition), 35 (3). pp. 165-169. ISSN 2173-5808

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Introduction: Neuroinflammation has recently been described in amyotrophic lateral sclerosis (ALS). However, the precise role of such proinflammatory cytokines as monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1� (MIP-1�) in ALS has not yet been determined. In this study, we determined cerebrospinal fluid (CSF) MCP-1 and MIP-1� levels and assessed their association with the duration and severity of ALS. Methods: Concentrations of MCP-1 and MIP-1� were determined in the CSF of 77 patients diagnosed with ALS and 13 controls. Cytokine levels were analysed in relation to ALS duration (< 12 months vs > 12 months) and severity (< 30 points vs > 30 points on the ALS Functional Rating Scale administered at hospital admission). Results: Higher CSF MIP-1� (10.68 pg/mL vs 4.69 pg/mL, P < .0001) and MCP-1 (234.89 pg/mL vs 160.95 pg/mL, P = .011) levels were found in the 77 patients with ALS compared to controls. There were no differences in levels of either cytokine in relation to disease duration or severity. However, we did observe a significant positive correlation between MIP-1� and MCP-1 in patients with ALS. Conclusions: The increase in MIP-1� and MCP-1 levels suggests that these cytokines may havea synergistic effect on ALS pathogenesis. However, in our cohort, no association was found witheither the duration or the clinical severity of the disease.

Tipo de elemento: Article
Palabras claves no controlados: Amyotrophic lateral sclerosis (ELA), Cytokines, MIP-1�, MCP-1, Neuroinflammation, Biomarkers
Materias: R Medicina > RC Medicina Interna, Psiquiatría, Neurología
Divisiones: Medicina
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
Martínez, H.R.NO ESPECIFICADONO ESPECIFICADO
Escamilla Ocañas, C.E.NO ESPECIFICADONO ESPECIFICADO
Camara Lemarroy, C.R.NO ESPECIFICADONO ESPECIFICADO
González Garza, M.T.NO ESPECIFICADONO ESPECIFICADO
Moreno Cuevas, J.E.NO ESPECIFICADONO ESPECIFICADO
García Sarreón, M.A.NO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 14 Oct 2020 17:29
Última modificación: 14 Oct 2020 17:29
URI: http://eprints.uanl.mx/id/eprint/20086

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