CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico

Salinas Santander, Mauricio Andrés y Cantú Salinas, Cristina Susana y Ocampo Candiani, Jorge y Suarez Valencia, Victor de Jesus y Ramirez Guerrero, Jennifer Guadalupe y Sánchez Domínguez, Celia Nohemí (2020) CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico. Anais Brasileiros de Dermatologia, 95 (3). pp. 283-288. ISSN 0365-0596

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Resumen

Background: Alopecia areata is an autoimmune disease that produces non-scarring hair loss around the body. Gene variants of the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene, a negative regulator of T-cell response, have been associated with a predisposition to autoimmune diseases in different populations; however, the involvement of these genetic variants in the development of AA is controversial. Objective: The present study evaluated the potential association of two CTLA4 gene variants with alopecia areata in a Mexican population. Methods: We genotyped +49AG (rs231775) and CT60 (rs3087243) variants in 50 AA patients and 100 healthy control participants through PCR-RFLP. Results: No statistical difference was observed for either of the gene variants regarding allele or genotype frequencies between AA patients and the controls when the parameters of family/personal history of autoimmune diseases or gender were considered (p > 0.05).Study limitations: Small sample size of patients and the data were obtained from NortheastMexico population.Conclusion: The genetic variants rs231775 and rs3087243 of the CTLA4 gene are not a risk factorfor the development of alopecia areata in the analyzed Mexican population

Tipo de elemento: Article
Palabras claves no controlados: Alopecia areata, Autoimmune diseases, Polymorphism, Single nucleotide
Materias: R Medicina > RL Dermatología
Divisiones: Medicina
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
Salinas Santander, Mauricio AndrésNO ESPECIFICADONO ESPECIFICADO
Cantú Salinas, Cristina SusanaNO ESPECIFICADONO ESPECIFICADO
Ocampo Candiani, JorgeNO ESPECIFICADONO ESPECIFICADO
Suarez Valencia, Victor de JesusNO ESPECIFICADONO ESPECIFICADO
Ramirez Guerrero, Jennifer GuadalupeNO ESPECIFICADONO ESPECIFICADO
Sánchez Domínguez, Celia NohemíNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 14 Oct 2020 17:43
Última modificación: 14 Oct 2020 17:43
URI: http://eprints.uanl.mx/id/eprint/20088

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