Clinical characteristics associated with the severity of Clostridium [Clostridioides] difficile infection in a tertiary teaching hospital from Mexico

Tijerina Rodríguez, Laura Esther y Garza González, Elvira y Martínez Meléndez, Adrián y Morfín Otero, Rayo y Camacho Ortiz, Adrián y Gonzalez Diaz, Esteban E. y Pérez Gómez, Héctor Raúl y Villarreal Treviño, Licet y Maldonado Garza, Héctor Jesús y Esparza Ahumada, Sergio y Rodríguez Noriega, Eduardo (2021) Clinical characteristics associated with the severity of Clostridium [Clostridioides] difficile infection in a tertiary teaching hospital from Mexico. Biomedical Journal. pp. 1-6. ISSN 23194170

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Background: Clostridium difficile infection (CDI) is a leading cause of healthcare-associated diarrhea worldwide. In this study, risk factors associated with the development of severe-complicated and recurrent outcomes in CDI patients in different age groups, including the non-elderly, were assessed in a third-level hospital. Methods: CDI cases were detected by clinical data and polymerase-chain-reaction (PCR). Clinical, demographic, epidemiological, and microbiological risk factors for CDI were evaluated. Results: During the study period, 248 out of 805 patients with nosocomial diarrhea were diagnosed with CDI and the majority were severe-complicated cases (87.90%). Female gender (OR 3.19, 95% CI 1.19e8.55, p ¼ 0.02) and lymphoma (OR 3.95, 95% CI 1.03e15.13, p ¼ 0.04) were risk factors for severe-complicated CDI. Mature adulthood (51e60 years) (OR 5.80, 95% CI 1.56e21.62, p ¼ 0.01), previous rifampicin use (OR 7.44, 95% CI 2.10e26.44, p ¼ 0.00), and neoplasm (solid malignant neoplasm or hematological malignancies) (OR 4.12, 95% CI 1.01e16.83, p ¼ 0.04) were risk factors for recurrent infection. Autoimmune disorders (OR 6.62, CI 95% 1.26e34.73, p ¼ 0.02), leukemia (OR 4.97, 95% CI 1.05e23.58, p ¼ 0.04), lymphoma (OR 3.79, 95% CI 1.03e12.07, p ¼ 0.04) and previous colistin treatment (OR 4.97, 95% CI 1.05e23.58, p ¼ 0.04) were risk factors for 30-day mortality. Conclusion: Newly identified risk factors for recurrent CDI were rifampicin treatment and age between 51 and 60 years; colistin treatment was identified as a risk factor for 30-day mortality. Previously identified risk factors for severe-complicated CDI were confirmed, but with a major impact on non-elderly patients.

Tipo de elemento: Article
Palabras claves no controlados: Severity, Clostridioides difficile, Recurrence, CDI.
Materias: R Medicina > RC Medicina Interna, Psiquiatría, Neurología
Divisiones: Medicina
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
Tijerina Rodríguez, Laura EstherNO ESPECIFICADONO ESPECIFICADO
Garza González, ElviraNO ESPECIFICADONO ESPECIFICADO
Martínez Meléndez, AdriánNO ESPECIFICADONO ESPECIFICADO
Morfín Otero, RayoNO ESPECIFICADONO ESPECIFICADO
Camacho Ortiz, AdriánNO ESPECIFICADONO ESPECIFICADO
Gonzalez Diaz, Esteban E.NO ESPECIFICADONO ESPECIFICADO
Pérez Gómez, Héctor RaúlNO ESPECIFICADONO ESPECIFICADO
Villarreal Treviño, LicetNO ESPECIFICADONO ESPECIFICADO
Maldonado Garza, Héctor JesúsNO ESPECIFICADONO ESPECIFICADO
Esparza Ahumada, SergioNO ESPECIFICADONO ESPECIFICADO
Rodríguez Noriega, EduardoNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 12 Nov 2021 18:26
Última modificación: 01 Mar 2024 21:19
URI: http://eprints.uanl.mx/id/eprint/22459

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