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Synergistic Antitumor Activity of Gramicidin/Lipophilic Bismuth Nanoparticles (BisBAL NPs) on Human Cervical Tumor Cells
Cabral Romero, Claudio y García Cuellar, Claudia María y Hernández Delgadillo, René y Sánchez Pérez, Yesennia y Meester, Irene y Solís Soto, Juan Manuel y Pineda Aguilar, Nayely y Chellam, Shankararaman (2021) Synergistic Antitumor Activity of Gramicidin/Lipophilic Bismuth Nanoparticles (BisBAL NPs) on Human Cervical Tumor Cells. Frontiers in Nanotechnology, 3. pp. 1-10. ISSN 2673-3013
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Texto
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Resumen
The objective of this study was to study the synergistic antitumor effect of lipophilic bismuth nanoparticles (BisBAL NPs) with the antibiotic solution Neo-Poly gramicidin on human cervical tumor cells. The effect of BisBAL NPs and Neo-Poly gramicidin solution on cervical cancer cell line (HeLa) was determined by the MTT cell viability assay and fluorescence microscopy. After a 24-h exposure to 0.1× Neo-Poly gramicidin HeLa cell growth decreased 94%. Fluorescence microscopy confirmed the antitumor effect cell death was higher among treated than among non-treated cells cells. Individually, gramicidin (0.04 mg/mL) inhibited HeLa tumor cell growth most (40%), and neomycin (0.04 mg/mL) least (21%). Gramicidin (0.3 mg/mL) in combination with different concentrations (1–150 μM) of BisBAL NPs had a synergistic antitumor effect against HeLa cells, reaching an < 86% tumor growth inhibition. As far as we know, we are the first to describe the antitumor activity of the antibiotic Neo-Poly gramicidin on a human cervical cancer cell line. The action mechanism of gramicidin/BisBAL NP is based on a strong damage on cell membrane and nucleus of tumor cells. A synergistic effect of gramicidin with BisBAL NPs may be useful as an alternative therapy for cervical cancer patients.
| Tipo de elemento: | Article | |||||||||||||||||||||||||||
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| Palabras claves no controlados: | antitumor activity, bismuth nanoparticles, cervical cancer, neomycin, polymyxin B, gramicidin | |||||||||||||||||||||||||||
| Materias: | T Tecnología > TP Tecnología Química | |||||||||||||||||||||||||||
| Divisiones: | Odontología | |||||||||||||||||||||||||||
| Usuario depositante: | Editor Repositorio | |||||||||||||||||||||||||||
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| Fecha del depósito: | 01 Jul 2022 20:20 | |||||||||||||||||||||||||||
| Última modificación: | 01 Jul 2022 20:20 | |||||||||||||||||||||||||||
| URI: | http://eprints.uanl.mx/id/eprint/23517 |
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