Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii

García Davis, Sara y Leal López, Karla Ivette y Molina Torres, Carmen Amelia y Vera Cabrera, Lucio y Díaz Marrero, Ana R. y Fernández, José J. y Carranza Rosales, Pilar y Viveros Valdez, José Ezequiel (2020) Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii. Marine drugs, 18. pp. 1-9. ISSN 1660-3397

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URL o página oficial: http://doi.org/10.3390/md18060287

Resumen

Marine environments represent a great opportunity for the discovery of compounds with a wide spectrum of bioactive properties. Due to their large variety and functions derived from natural selection, marine natural products may allow the identification of novel drugs based not only on newly discovered bioactive metabolites but also on already known compounds not yet thoroughly investigated. Since drug resistance has caused an increase in infections by Mycobacterium tuberculosis and nontuberculous mycobacteria, the re-evaluation of known bioactive metabolites has been suggested as a good approach to addressing this problem. In this sense, this study presents an evaluation of the in vitro effect of laurinterol and aplysin, two brominated sesquiterpenes isolated from Laurencia johnstonii, against nine M. tuberculosis strains and six nontuberculous mycobacteria (NTM). Laurinterol exhibited good antimycobacterial activity, especially against nontuberculous mycobacteria, being remarkable its effect against Mycobacterium abscessus, with minimum inhibitory concentration (MIC) values lower than those of the reference drug imipenem. This study provides further evidence for the antimycobacterial activity of some sesquiterpenes from L. johnstonii, which can be considered interesting lead compounds for the discovery of novel molecules to treat NTM infections.

Tipo de elemento:

Article

Palabras claves no controlados:

productos naturales marinos, Laurencia, sesquiterpenos bromados, antimicobacteriano, micobacterias no tuberculosas, tuberculosis

Materias:

Q Ciencia > QR Microbiología

Divisiones:

Ciencias Biológicas

Usuario depositante:

Editor Repositorio

Creadores:

Creador	Email	ORCID
García Davis, Sara	NO ESPECIFICADO	NO ESPECIFICADO
Leal López, Karla Ivette	NO ESPECIFICADO	NO ESPECIFICADO
Molina Torres, Carmen Amelia	carmelia7@hotmail.com	NO ESPECIFICADO
Vera Cabrera, Lucio	NO ESPECIFICADO	NO ESPECIFICADO
Díaz Marrero, Ana R.	NO ESPECIFICADO	NO ESPECIFICADO
Fernández, José J.	NO ESPECIFICADO	NO ESPECIFICADO
Carranza Rosales, Pilar	NO ESPECIFICADO	NO ESPECIFICADO
Viveros Valdez, José Ezequiel	jose.viverosvld@uanl.edu.mx	orcid.org/0000-0001-5944-7972