Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models

Wibetoe, Grunde y Sexton, Joseph y Ikdahl, Eirik y Rollefstad, Silvia y Kitas, George D. y Riel, Piet van y Gabriel, Sherine y Kvien, Tore K. y Douglas, Karen y Sandoo, Aamer y Arts, Elke E. y Wållberg Jonsson, Solveig y Rantapää Dahlqvist, Solbritt y Karpouzas, George y Dessein, Patrick H. y Tsang, Linda y El Gabalawy, Hani y Hitchon, Carol A. y Pascual Ramos, Virginia y Contreas Yañes, Irazu y Sfikakis, Petros P. y González Gay, Miguel A. y Colunga Pedraza, Iris Jazmín y Galarza Delgado, Dionicio Ángel y Azpiri López, José Ramón y Crowson, Cynthia S. y Grete Semb, Anne (2020) Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models. Arthritis research & therapy, 22 (1). pp. 1-10. ISSN 1478-6354

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Resumen

Background In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability of available risk age models in prediction of CVD in rheumatoid arthritis (RA). Secondly, we also evaluated the performance of risk age models in subgroups based on RA disease characteristics. Methods RA patients aged 30–70 years were included from an international consortium named A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA). Prior CVD and diabetes mellitus were exclusion criteria. The discriminatory ability of specific risk age models was evaluated using c-statistics and their standard errors after calculating time until fatal or non-fatal CVD or last follow-up. Results A total of 1974 patients were included in the main analyses, and 144 events were observed during follow-up, the median follow-up being 5.0 years. The risk age models gave highly correlated results, demonstrating R 2 values ranging from 0.87 to 0.97. However, risk age estimations differed > 5 years in 15–32% of patients. C-statistics ranged 0.68–0.72 with standard errors of approximately 0.03. Despite certain RA characteristics being associated with low c-indices, standard errors were high. Restricting analysis to European RA patients yielded similar results. Conclusions The cardiovascular risk age and vascular age models have comparable performance in predicting CVD in RA patients. The influence of RA disease characteristics on the predictive ability of these prediction models remains inconclusive.

Tipo de elemento: Article
Palabras claves no controlados: Edad de riesgo cardiovascular, Edad vascular, Enfermedad cardiovascular, Factores de riesgo, Artritis reumatoide
Materias: R Medicina > RC Medicina Interna, Psiquiatría, Neurología
Divisiones: Medicina
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
Wibetoe, GrundeNO ESPECIFICADONO ESPECIFICADO
Sexton, JosephNO ESPECIFICADONO ESPECIFICADO
Ikdahl, EirikNO ESPECIFICADONO ESPECIFICADO
Rollefstad, SilviaNO ESPECIFICADONO ESPECIFICADO
Kitas, George D.NO ESPECIFICADONO ESPECIFICADO
Riel, Piet vanNO ESPECIFICADONO ESPECIFICADO
Gabriel, SherineNO ESPECIFICADONO ESPECIFICADO
Kvien, Tore K.NO ESPECIFICADONO ESPECIFICADO
Douglas, KarenNO ESPECIFICADONO ESPECIFICADO
Sandoo, AamerNO ESPECIFICADONO ESPECIFICADO
Arts, Elke E.NO ESPECIFICADONO ESPECIFICADO
Wållberg Jonsson, SolveigNO ESPECIFICADONO ESPECIFICADO
Rantapää Dahlqvist, SolbrittNO ESPECIFICADONO ESPECIFICADO
Karpouzas, GeorgeNO ESPECIFICADONO ESPECIFICADO
Dessein, Patrick H.NO ESPECIFICADONO ESPECIFICADO
Tsang, LindaNO ESPECIFICADONO ESPECIFICADO
El Gabalawy, HaniNO ESPECIFICADONO ESPECIFICADO
Hitchon, Carol A.NO ESPECIFICADONO ESPECIFICADO
Pascual Ramos, VirginiaNO ESPECIFICADONO ESPECIFICADO
Contreas Yañes, IrazuNO ESPECIFICADONO ESPECIFICADO
Sfikakis, Petros P.NO ESPECIFICADONO ESPECIFICADO
González Gay, Miguel A.NO ESPECIFICADONO ESPECIFICADO
Colunga Pedraza, Iris JazmínNO ESPECIFICADONO ESPECIFICADO
Galarza Delgado, Dionicio ÁngelNO ESPECIFICADONO ESPECIFICADO
Azpiri López, José RamónNO ESPECIFICADONO ESPECIFICADO
Crowson, Cynthia S.NO ESPECIFICADONO ESPECIFICADO
Grete Semb, AnneNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 14 Oct 2022 20:23
Última modificación: 14 Oct 2022 20:23
URI: http://eprints.uanl.mx/id/eprint/24017

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