Effects of pericytes and colon cancer stem cells in the tumor microenvironment

Garza Treviño, Elsa N. y Delgado González, Paulina y Valencia Salgado, Carlos I. y Martínez Garza, Alejandra Mayela (2019) Effects of pericytes and colon cancer stem cells in the tumor microenvironment. Cancer Cell International, 19 (1). pp. 1-12. ISSN 1475-2867

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URL o página oficial: https://cancerci.biomedcentral.com/articles/10.118...

Resumen

Colorectal cancer (CRC) is one type of tumor with the highest frequency and mortality worldwide. Although current treatments increase patient survival, it is important to detect CRC in early stages; however, most CRC, despite responding favorably to treatment, develop resistance and present recurrence, a situation that will inevitably lead to death. In recent years, it has been shown that the main reason for drug resistance is the presence of colon cancer stem cells (CSC). Pericytes are also capable of tumor homing and are important cellular components of the tumor microenvironment (TME), contributing to the formation of vessels and promoting metastasis; however, they have not been considered very important as a therapeutic target in cancer. In this review, we highlight the contribution of pericytes and cancer stem cells to some classical hallmarks of cancer, namely, tumor angiogenesis, growth, metastasis, and evasion of immune destruction, and discuss therapies targeting pericytes and cancer stem cells in CRC.

Tipo de elemento:

Article

Palabras claves no controlados:

Células madre cancerosas; Pericitos; Tratamiento del cáncer colorrectal; Quimiorresistencia.

Materias:

R Medicina > RC Medicina Interna, Psiquiatría, Neurología

Divisiones:

Medicina

Usuario depositante:

Editor Repositorio

Creadores:

Creador	Email	ORCID
Garza Treviño, Elsa N.	NO ESPECIFICADO	orcid.org/0000-0002-1042-4603
Delgado González, Paulina	NO ESPECIFICADO	NO ESPECIFICADO
Valencia Salgado, Carlos I.	NO ESPECIFICADO	NO ESPECIFICADO
Martínez Garza, Alejandra Mayela	NO ESPECIFICADO	NO ESPECIFICADO