Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: a cross kingdom computational approach

Sánchez Romo, Daniel y Hernández Vásquez, Cesar I. y Pereyra Alférez, Benito y García García, Jorge H. (2022) Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: a cross kingdom computational approach. Non-coding RNA Research, 7 (2). pp. 89-97. ISSN 2468-0540

[img]
Vista previa
Texto
27827.pdf - Versión Publicada
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (2MB) | Vista previa

Resumen

Plant-derived miRNAs can be found in the human body after dietary intake, and they can affect post-transcriptional gene regulation in human. It is important to identify targets to determine the possible effects in human genes by using computational approach. In this study, 787 possible mRNAs human targets were predicted by 84 miRNAs of wheat. A total of 14 miRNAs were identified with individual binding to 33 mRNAs associated with schizophrenia, epilepsy, neurodevelopmental disorders, and various cancers, located in the 3′UTR of the mRNA. A functional enrichment was carried out, where the results showed associations to pathways such as dopaminergic synapse (hsa04728), and signaling pathways, significantly associated with the target genes. The prediction of target mRNAs in humans by wheat miRNAs, offer candidates that could facilitate the search and verification, which could be of relevance for future projects and there for contribute in the therapeutic treatment of various human diseases.

Tipo de elemento: Article
Palabras claves no controlados: microRNA, mRNA, Triticum aestivum, Human, Functional enrichment
Materias: Q Ciencia > QR Microbiología
Divisiones: Ciencias Biológicas
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
Sánchez Romo, DanielNO ESPECIFICADONO ESPECIFICADO
Hernández Vásquez, Cesar I.NO ESPECIFICADONO ESPECIFICADO
Pereyra Alférez, BenitoNO ESPECIFICADONO ESPECIFICADO
García García, Jorge H.NO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 26 Ago 2024 17:06
Última modificación: 26 Ago 2024 17:07
URI: http://eprints.uanl.mx/id/eprint/27827

Actions (login required)

Ver elemento Ver elemento

Downloads

Downloads per month over past year