Eltrombopag, Low-Dose Rituximab, and High-Dose Dexamethasone Combination for Patients with Newly Diagnosed Immune Thrombocytopenia: A Pilot "Total Therapy" Study

Gómez Almaguer, David y Cantú Rodríguez, Olga Graciela y Gutiérrez Aguirre, César Homero y Jaime Pérez, José Carlos y Tarín Arzaga, Luz del Carmen y Sánchez Cárdenas, Mónica y Lozano Morales, Rosa Elena y Sotomayor Duque, Guillermo y Cárdenas Araujo, Daniela y Gómez de León, Andrés y Santana Hernández, Paola y Colunga Pedraza, Perla Rocío (2016) Eltrombopag, Low-Dose Rituximab, and High-Dose Dexamethasone Combination for Patients with Newly Diagnosed Immune Thrombocytopenia: A Pilot "Total Therapy" Study. Blood, 128 (22). p. 1369. ISSN 0006-4971

Vista previa

Texto 1035.pdf - Versión Publicada Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (153kB) | Vista previa

Resumen

Immune thrombocytopenia (ITP) is an autoimmune disorder that results from platelet destruction and production suppression. Frontline-therapy includes corticosteroids, intravenous immune globulin or anti-D immunoglobulin. Single-agent treatments have not been successful in inducing prolonged remission, as relapse will occur in approximately 50% of patients. Low-dose rituximab (100 mg) has been used for the treatment of ITP, showing an activity almost similar to the 375 mg/m2 standard dose. We and others have reported sustained response rates ranging from 58% to 76% using rituximab plus dexamethasone as a frontline therapy. Eltrombopag is a thrombopoietin nonpeptide mimetic that has been shown to raise platelet count in chronic ITP, and we have previously reported eltrombopag/ dexamethasone as a feasible frontline therapy for ITP reaching 100% response rates.The lack of sustained response in many adult patients with newly diagnosed acute ITP has stimulated the search for a treatment that modifies the natural course of the disease.

Tipo de elemento:	Article
Materias:	R Medicina > RC Medicina Interna, Psiquiatría, Neurología
Divisiones:	Medicina
Usuario depositante:	Editor Repositorio
Creadores:	Creador Email ORCID Gómez Almaguer, David dgomezalmaguer@gmail.com orcid.org/0000-0002-0460-6427 Cantú Rodríguez, Olga Graciela NO ESPECIFICADO NO ESPECIFICADO Gutiérrez Aguirre, César Homero NO ESPECIFICADO NO ESPECIFICADO Jaime Pérez, José Carlos NO ESPECIFICADO NO ESPECIFICADO Tarín Arzaga, Luz del Carmen NO ESPECIFICADO NO ESPECIFICADO Sánchez Cárdenas, Mónica dra.monicasanchez87@gmail.com NO ESPECIFICADO Lozano Morales, Rosa Elena NO ESPECIFICADO NO ESPECIFICADO Sotomayor Duque, Guillermo NO ESPECIFICADO NO ESPECIFICADO Cárdenas Araujo, Daniela NO ESPECIFICADO NO ESPECIFICADO Gómez de León, Andrés NO ESPECIFICADO NO ESPECIFICADO Santana Hernández, Paola NO ESPECIFICADO NO ESPECIFICADO Colunga Pedraza, Perla Rocío NO ESPECIFICADO orcid.org/0000-0002-9937-439X
Fecha del depósito:	19 Ene 2026 20:57
Última modificación:	28 Mayo 2026 16:23
URI:	http://eprints.uanl.mx/id/eprint/29118

Actions (login required)

Ver elemento