Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns

Treviño Garza, Consuelo y Estrada Zúñiga, Cynthia M. y Mancillas Adame, Leonardo Guadalupe y Villarreal Martínez, Laura y Villarreal Pérez, Jesús Z. y Rodríguez Balderrama, Isaías y Montes Tapia, Fernando F. y De la O. Cavazos, Manuel E. (2016) Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns. Journal of Clinical Research in Pediatric Endocrinology, 8 (3). pp. 321-324. ISSN 13085727

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URL o página oficial: http://doi.org/10.4274/jcrpe.2693

Resumen

Objective: Most adipose tissue programming is realized in early life. Also, the postnatal three months, rather than the later phases of infancy, may be more relevant in the development of an adverse cardiometabolic risk profile. The adipokines phenotype, as a predictor of early-life weight gain, has been recently explored in cord blood. To determine whether in addition to leptin levels in cord samples, adiponectin, interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), resistin, plasminogen activator inhibitor-1 (PAI-1), and tumor necrosis factor alpha (TNF-α) levels improve weight gain prediction during the first three months of life. Methods: Adiponectin, IL-6, MCP-1, leptin, resistin, PAI-1, and TNF-α were measured by multiplex immunoassay in a subsample of 86 healthy term newborns. Results: Leptin levels significantly predicted weight gain at 3 months of followup (r2=0.09, p=0.006). In the multivariate analysis, including additional adipokines in the model, stepwise or all at once, did not increase the prediction of weight gain after the first three months of life. Conclusion: Adding adiponectin, IL-6, MCP-1, resistin, PAI-1, and TNF-α to the prediction model of weight gain in healthy newborns did not prove to be useful. It is probable that their relative contribution to weight gain is not important. Only leptin was relevant as a predictor of weight gain at the 3-month endpoint.

Tipo de elemento:

Article

Palabras claves no controlados:

Leptina; Adipocinas; Predicción; Aumento de peso; Recién nacido

Materias:

R Medicina > RJ Pediatría

Divisiones:

Medicina

Usuario depositante:

Editor Repositorio

Creadores:

Creador	Email	ORCID
Treviño Garza, Consuelo	cotrevin@hotmail.com	NO ESPECIFICADO
Estrada Zúñiga, Cynthia M.	NO ESPECIFICADO	NO ESPECIFICADO
Mancillas Adame, Leonardo Guadalupe	leomancillas@gmail.com	NO ESPECIFICADO
Villarreal Martínez, Laura	dr_lauravillarreal@hotmail.com	orcid.org/0000-0003-0313-7312
Villarreal Pérez, Jesús Z.	NO ESPECIFICADO	NO ESPECIFICADO
Rodríguez Balderrama, Isaías	irb442000@yahoo.com.mx	NO ESPECIFICADO
Montes Tapia, Fernando F.	NO ESPECIFICADO	NO ESPECIFICADO
De la O. Cavazos, Manuel E.	NO ESPECIFICADO	NO ESPECIFICADO