CD20 expression in B-cell precursor acute lymphoblastic leukemia is common in Mexican patients and lacks a prognostic value

Solano Genesta, Manuel y Tarín Arzaga, Luz y Velasco Ruiz, Ileana y Lutz Presno, Julia A. y González Llano, Óscar y Mancías Guerra, Consuelo y Rodríguez Romo, Laura y Ruiz Delgado, Guillermo J. y Ruiz Argüelles, Guillermo José y Jaime Pérez, José Carlos y Gómez Almaguer, David (2012) CD20 expression in B-cell precursor acute lymphoblastic leukemia is common in Mexican patients and lacks a prognostic value. Hematology, 17 (2). pp. 66-70. ISSN 1607-8454

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Resumen

Classification of acute lymphoblastic leukemia (ALL) by flow cytometric immunophenotyping characterizes the disease and delineates potential therapeutic intervention. We retrospectively analyzed CD20 expression in 143 patients with newly diagnosed precursor B-cell ALL. CD20 was observed in 61% of patients at diagnosis. There was no correlation between CD20 expression and age, white blood cell count, or cytogenetic abnormalities. Despite the fact that CD20-positive ALL patients had a tendency toward a worse outcome, there was no significant difference between patients with and without CD20 expression in 3-year overall survival 65 vs. 82% (P = 0.14), and cumulative incidence of relapse 36 vs. 18% (P = 0.3) in pediatric patients and 51 vs. 53% (P = 0.31) and 35 vs. 38% (P = 0.6) in adults, respectively. In conclusion, CD20 expression appears to be more common in Mexican patients with newly diagnosed precursor B-cell ALL higher than in Caucasian populations and lacks prognostic value.

Tipo de elemento:

Article

Palabras claves no controlados:

CD20, Acute lymphoblastic leukemia, Prognostic factor

Divisiones:

Medicina

Usuario depositante:

Editor Repositorio

Creadores:

Creador	Email	ORCID
Solano Genesta, Manuel	NO ESPECIFICADO	NO ESPECIFICADO
Tarín Arzaga, Luz	NO ESPECIFICADO	NO ESPECIFICADO
Velasco Ruiz, Ileana	NO ESPECIFICADO	NO ESPECIFICADO
Lutz Presno, Julia A.	NO ESPECIFICADO	NO ESPECIFICADO
González Llano, Óscar	NO ESPECIFICADO	NO ESPECIFICADO
Mancías Guerra, Consuelo	consuelo@mancias.com	orcid.org/0000-0003-4292-8635
Rodríguez Romo, Laura	NO ESPECIFICADO	NO ESPECIFICADO
Ruiz Delgado, Guillermo J.	NO ESPECIFICADO	NO ESPECIFICADO
Ruiz Argüelles, Guillermo José	gruiz1@clinicaruiz.com	NO ESPECIFICADO
Jaime Pérez, José Carlos	NO ESPECIFICADO	NO ESPECIFICADO
Gómez Almaguer, David	dgomezalmaguer@gmail.com	orcid.org/0000-0002-0460-6427