Genetic Insights into Breast Cancer in Northeastern Mexico: Unveiling Gene–Environment Interactions and Their Links to Obesity and Metabolic Diseases

Gallardo Blanco, Hugo Leonid y Garza Rodríguez, María de Lourdes y Pérez Ibave, Diana Cristina y Burciaga Flores, Carlos Horacio y Salinas, Victor y González, Moises y Piñeiro, Rafael y Cerda, Ricardo y Vidal Gutiérrez, Oscar y Sánchez Domínguez, Celia Nohemí (2025) Genetic Insights into Breast Cancer in Northeastern Mexico: Unveiling Gene–Environment Interactions and Their Links to Obesity and Metabolic Diseases. Cancers, 17 (6). pp. 982-1009. ISSN 2072-6694

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URL o página oficial: https://www.mdpi.com/2072-6694/17/6/982

Resumen

Background: Breast cancer (BC), one of the most common cancers, has increased in Mexico during the past decade, along with other chronic and metabolic diseases.Methods: Herein, we analyzed 121 SNPs (85 SNPs related to BC and/or glucose-associated metabolic pathways and 36 SNP classified as ancestry markers) in 92 confirmed BC cases and 126 unaffected BC women from Northeastern Mexico. The relationship of these 121 SNPs with BC, considering BMI, menopause status, and age as cofactors, was explored using a gene–environment (G × E) interaction multi-locus model. Results: Twelve gene variants were significantly associated with BC: three located in exome (rs3856806PPARG, rs12792229 MMP8, and rs5218 KCNJ11-ABCC8), and nine in non-coding regions, which are involved in accelerated decay of the mRNA transcripts, regulatory regions, and flanking regions (rs3917542 PON1; rs3750804 and rs3750805 TCF7L2; rs1121980 and rs3751812 FTO; rs12946618 RPTOR; rs2833483 SCAF4; rs11652805 AMZ2P1-GNA13; and rs1800955 SCT-DEAF1-DRD4). Conclusions: This study identified an association between BC and menopause, age (above 45), obesity, and overweight status with gene variants implicated in diabetes mellitus, obesity, insulin resistance, inflammation, and remodeling of the extracellular matrix.

Tipo de elemento:

Article

Palabras claves no controlados:

Perspectivas genéticas sobre el cáncer de mama en el noreste de México: Descubriendo las interacciones gen-ambiente y su relación con la obesidad y las enfermedades metabólicas Cáncer de mama; Variantes genéticas de riesgo; Obesidad; Sobrepeso; Resistencia a la insulina; Inflamación; Menopausia; Interacciones Gen-ambiente; MMP8; FTO

Materias:

R Medicina > RC Medicina Interna, Psiquiatría, Neurología

Divisiones:

Medicina

Usuario depositante:

Dr.C. Hugo Gallardo Blanco

Creadores:

Creador	Email	ORCID
Gallardo Blanco, Hugo Leonid	hugo.gallardobl@uanl.edu.mx	orcid.org/0000-0002-7816-4967
Garza Rodríguez, María de Lourdes	maria.garzarg@uanl.edu.mx	orcid.org/0000-0001-7096-2713
Pérez Ibave, Diana Cristina	dperezi@uanl.edu.mx	orcid.org/0000-0002-7816-4967
Burciaga Flores, Carlos Horacio	carlos.hburciaga@gmail.com	orcid.org/0000-0002-7723-8354
Salinas, Victor	NO ESPECIFICADO	NO ESPECIFICADO
González, Moises	NO ESPECIFICADO	NO ESPECIFICADO
Piñeiro, Rafael	NO ESPECIFICADO	NO ESPECIFICADO
Cerda, Ricardo	NO ESPECIFICADO	NO ESPECIFICADO
Vidal Gutiérrez, Oscar	oscar.vidalgtz@uanl.edu.mx	orcid.org/0000-0003-3723-8525
Sánchez Domínguez, Celia Nohemí	celia.sanchezdm@uanl.edu.mx	orcid.org/0000-0002-3444-9565