![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Assessment of biochemical parameters and characterization of {TNFalpha} -308G/A and {PTPN}22 +1858C/T gene polymorphisms in the risk of obesity in adolescents
Salinas Santander, Mauricio Andrés y León Cachón, Rafael Baltazar y Cepeda Nieto, Ana Cecilia y Sánchez Domínguez, Celia Nohemí y González Zavala, Maria Antonia y Gallardo Blanco, Hugo Leonid y Esparza González, Sandra Cecilia y González Madrazo, Miguel Ángel (2016) Assessment of biochemical parameters and characterization of {TNFalpha} -308G/A and {PTPN}22 +1858C/T gene polymorphisms in the risk of obesity in adolescents. Biomedical Reports, 4 (1). pp. 107-111. ISSN 2049-9434, 2049-9442
|
Texto
Salinas-Santander et al. - 2016 - Assessment of biochemical parameters and character.pdf - Versión Publicada Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (476kB) | Vista previa |
Resumen
Obesity is currently considered an inflammatory condition associated with autoimmune diseases, suggesting a common origin. Among other factors, candidate genes may explain the development of this disease. Polymorphisms in the tumor necrosis factor α (TNFα) and lymphoid protein tyrosine phosphatase (PTPN22) genes lead to an increased risk to development of immune and inflammatory diseases. The aim of the present study was to analyze the biochemical parameters and the effect of the TNFα -308G/A and PTPN22 +1858C/T polymorphisms in the susceptibility of adolescents to obesity. A group of 253 adolescent subjects were recruited and classified as obese, overweight or normal weight according to their nutritional status. Anthropometric measurements, clinical and biochemical data were analyzed. DNA was extracted from peripheral blood samples by the phenol-chloroform method, and TNFα -308G/A and PTPN22 1858C/T polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism assays. Clinical, genetic and biochemical parameters were analyzed to determine the existence of a possible association with the development of obesity. Statistically significant differences in body mass index, insulin, triglyceride levels and homeostatic model assessment for insulin resistance (HOMA-IR) index were observed among the three groups analyzed (P≤0.05). The studied polymorphisms did not confer a risk for developing obesity in the analyzed population (P>0.05); however, significantly low levels of insulin and decreased rates of HOMA-IR were observed in the 1858 CT genotype carriers of the PTPN22 gene. In conclusion, no association between the TNFα -308G/A and PTPN22 +1858C/T polymorphisms and the risk to development of obesity in the adolescent population analyzed was observed. However, the 1858 CT genotype of the PTPN22 gene was associated with variations of certain biochemical parameters analyzed.
| Tipo de elemento: | Article | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Palabras claves no controlados: | Mexican population, PCR-RFLP, PTPN22 +1858C/T, TNFalpha -308G/A, Autoimmune diseases, Inflammatory, Obesity | |||||||||||||||||||||||||||
| Materias: | CONACYT > Medicina y Ciencias de la Salud | |||||||||||||||||||||||||||
| Divisiones: | Medicina | |||||||||||||||||||||||||||
| Usuario depositante: | Dr.C. Hugo Gallardo Blanco | |||||||||||||||||||||||||||
| Creadores: |
|
|||||||||||||||||||||||||||
| Fecha del depósito: | 25 Sep 2026 14:56 | |||||||||||||||||||||||||||
| Última modificación: | 25 Sep 2026 14:56 | |||||||||||||||||||||||||||
| URI: | http://eprints.uanl.mx/id/eprint/31439 |
orcid.org/0000-0002-3444-9565Actions (login required)
 |
Ver elemento |
Descargar estadísticas
Descargar estadísticas
