Nanoparticles for death induced gene therapy in cancer (Review)

Roacho Pérez, Jorge A. y Gallardo Blanco, Hugo L. y Sánchez Domínguez, Margarita y García Casillas, Perla E. y Chapa González, Christian y Sánchez Domínguez, Celia Nohemí (2017) Nanoparticles for death induced gene therapy in cancer (Review). Molecular Medicine Reports. ISSN 1791-2997, 1791-3004

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URL o página oficial: http://www.spandidos-publications.com/10.3892/mmr....

Resumen

Due to the high toxicity and side effects of the use of traditional chemotherapy in cancer, scientists are working on the development of alternative therapeutic technologies. An example of this is the use of death-induced gene therapy. This therapy consists of the killing of tumor cells via transfection with plasmid {DNA} ({pDNA}) that contains a gene which produces a protein that results in the apoptosis of cancerous cells. The cell death is caused by the direct activation of apoptosis (apoptosis-induced gene therapy) or by the protein toxic effects (toxin-induced gene therapy). The introduction of {pDNA} into the tumor cells has been a challenge for the development of this therapy. The most recent implementation of gene vectors is the use of polymeric or inorganic nanoparticles, which have biological and physicochemical properties (shape, size, surface charge, water interaction and biodegradation rate) that allow them to carry the {pDNA} into the tumor cell. Furthermore, nanoparticles may be functionalized with specific molecules for the recognition of molecular markers on the surface of tumor cells. The binding between the nanoparticle and the tumor cell induces specific endocytosis, avoiding toxicity in healthy cells. Currently, there are no clinical protocols approved for the use of nanoparticles in death-induced gene therapy. There are still various challenges in the design of the perfect transfection vector, however nanoparticles have been demonstrated to be a suitable candidate. This review describes the role of nanoparticles used for {pDNA} transfection and key aspects for their use in death-induced gene therapy.

Tipo de elemento:

Article

Palabras claves no controlados:

DNA, Genetic Therapy, Genetic Vectors, Nanomedicine, Nanoparticles, Neoplasms, Plasmids, Transfection

Materias:

CONACYT > Biología y Química
CONACYT > Ingeniería y Tecnología
CONACYT > Medicina y Ciencias de la Salud

Divisiones:

Medicina

Usuario depositante:

Dr.C. Hugo Gallardo Blanco

Creadores:

Creador	Email	ORCID
Roacho Pérez, Jorge A.	NO ESPECIFICADO	NO ESPECIFICADO
Gallardo Blanco, Hugo L.	hugo.gallardobl@uanl.edu.mx	orcid.org/0000-0002-7816-4967
Sánchez Domínguez, Margarita	margarita.sanchez@cimav.edu.mx	orcid.org/0000-0003-4755-4441
García Casillas, Perla E.	NO ESPECIFICADO	NO ESPECIFICADO
Chapa González, Christian	NO ESPECIFICADO	NO ESPECIFICADO
Sánchez Domínguez, Celia Nohemí	celia.sanchezdm@uanl.edu.mx	orcid.org/0000-0002-3444-9565