Development of a Chitosan-Poloxamer 407 Copolymer as a Curcumin Carrier System

Herrera Alonso, Alejandra Estefania y Longoria García, Samuel y Gallardo Blanco, Hugo Leonid y Sánchez Domínguez, Celia Nohemí y Sánchez Domínguez, Margarita (2025) Development of a Chitosan-Poloxamer 407 Copolymer as a Curcumin Carrier System. In: A Cross-Disciplinary Exploration of {STEM}. Springer Nature Switzerland, pp. 242-250. ISBN 978-3-031-99986-4 978-3-031-99987-1

Texto
Capitulo Libro -Development of a Chitosan-Poloxamer- 10 Ago 2025 E-Book A Cross-Disciplinary Exploration of STEM_Compressed.pdf - Versión Publicada
Restricted to Solo usuarios registrados
Available under License Creative Commons Attribution Non-commercial No Derivatives.
Download (2MB)

URL o página oficial: https://link.springer.com/10.1007/978-3-031-99987-...

Resumen

Chitosan is a versatile biopolymer that has multiple biomedical appli-cations due to its properties of biocompatibility, biodegradability and antimicrobial activity. However, one of its limitations is that its high polarity makes it difficult to load liposoluble active ingredients such as curcumin, a phenolic compound commonly used for its anticancer applications thanks to its antioxidant properties. Therefore, in this work we seek the incorporation of curcumin into poloxamer micelles and subsequently graft chitosan to achieve a synergy between the prop-erties of both compounds. First, the graft is obtained through several steps such as poloxamer activation, formation of the imine group and reduction to obtain the copolymer, then the characterization is carried out by FTIR-ATR, Raman spec-troscopy, the encapsulation efficiency of curcumin is also evaluated, achieving a higher percentage of charge in the copolymer with respect to chitosan and the in vitro biocompatibility is also evaluated by hemolysis and cytotoxicity tests, pre-senting better biocompatibility properties when adding curcumin to the copolymer, so this copolymer based on chitosan and poloxamer 407 can be considered as a promising candidate for its application as a release system for liposoluble active ingredients.

Tipo de elemento:

Sección de libro.

Palabras claves no controlados:

Chitosan, Poloxamer, Curcumin, Drug Carriers, Hydrogels, Drug Delivery Systems

Materias:

CONACYT > Biología y Química
CONACYT > Ingeniería y Tecnología
CONACYT > Medicina y Ciencias de la Salud

Divisiones:

Medicina

Usuario depositante:

Dr.C. Hugo Gallardo Blanco

Creadores:

Creador	Email	ORCID
Herrera Alonso, Alejandra Estefania	alejandra.herrera@cimav.edu.mx	orcid.org/0000-0003-2009-1512
Longoria García, Samuel	samuel.longoriagr@uanl.edu.mx	orcid.org/0000-0002-4056-5343
Gallardo Blanco, Hugo Leonid	hugo.gallardobl@uanl.edu.mx	orcid.org/0000-0002-7816-4967
Sánchez Domínguez, Celia Nohemí	celia.sanchezdm@uanl.edu.mx	orcid.org/0000-0002-3444-9565
Sánchez Domínguez, Margarita	margarita.sanchez@cimav.edu.mx	orcid.org/0000-0003-4755-4441