Impact of an exercise program on acylcarnitines
in obesity: a prospective controlled study
Rodríguez Gutiérrez, René y Lavalle González, Fernando Javier y Martínez Garza, Laura Elia y Landeros Olvera, Erick Alberto y López Alvarenga, Juan Carlos y Torres Sepúlveda, María Rosario y González González, José Gerardo y Mancillas Adame, Leonardo G. y Salazar González, Bertha Cecilia y Villarreal Pérez, Jesús Zacarías
(2012)
Impact of an exercise program on acylcarnitines
in obesity: a prospective controlled study.
Journal of the International Society of Sports Nutrition, 9 (22).
pp. 1-8.
ISSN 1550-2783
Resumen
Background: Acylcarnitine (AC) transport dysfunction into the mitochondrial matrix is one of the
pathophysiological mechanisms of type 2 diabetes mellitus (DM). The effect of an aerobic exercise (AE) program on
this condition in obese subjects without DM is unclear.
Methods: A prospective, randomized, longitudinal, interventional study in a University Research Center involved a
10-week AE program in 32 women without DM and a body mass index (BMI) greater than 27 kg/m2. (Cases n = 17;
Controls n = 15). The primary objective was to evaluate the influence of a controlled AE program on beta-oxidation
according to modifications in short, medium, and long-chain ACs. Secondary objectives were to define the
behavior of amino acids, and the correlation between these modifications with metabolic and
anthropometric markers.
Results: The proportion of dropouts was 17% and 6% in controls and cases, respectively. In cases there was a
significant reduction in total carnitine (30.40 [95% CI 28.2 to 35.6]) vs. (29.4 [CI 95% 25.1 to 31.7]) p=0.0008 and longchain
AC C14 (0.06 [95% CI 0.05 to 0.08]) vs. (0.05 [95% CI 0.05 to 0.09]) p=0.005 and in C18 (0.31 [95% CI 0.27 to 0.45])
vs. (0.28 [95% CI 0.22 to 0.32]) p=0.03. Free fatty acid levels remained without change during the study in both groups.
Conclusion: In conclusion, a controlled 10-week AE program improved beta-oxidation by reducing long-chain ACs.
This finding highlights the importance that AE might have in avoiding or reverting lipotoxicity, and in consequence,
improving insulin sensitivity and pancreatic beta cell functional reserve.
Keywords: Beta-oxidation, Aerobic exercise, Diabetes mellitus, Overweight, Obesity, Lipotoxicity
3,
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Tipo de elemento: |
Article
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Palabras claves no controlados: |
Beta-oxidation, Aerobic exercise, Diabetes mellitus, Overweight, Obesity, Lipotoxicity |
Materias: |
R Medicina > RT Enfermería |
Divisiones: |
Enfermería |
Usuario depositante: |
Admin Eprints
|
Creadores: |
Creador | Email | ORCID |
---|
Rodríguez Gutiérrez, René | NO ESPECIFICADO | NO ESPECIFICADO | Lavalle González, Fernando Javier | drfernandolavalle@hotmail.com | NO ESPECIFICADO | Martínez Garza, Laura Elia | NO ESPECIFICADO | NO ESPECIFICADO | Landeros Olvera, Erick Alberto | NO ESPECIFICADO | NO ESPECIFICADO | López Alvarenga, Juan Carlos | NO ESPECIFICADO | NO ESPECIFICADO | Torres Sepúlveda, María Rosario | NO ESPECIFICADO | NO ESPECIFICADO | González González, José Gerardo | NO ESPECIFICADO | NO ESPECIFICADO | Mancillas Adame, Leonardo G. | NO ESPECIFICADO | NO ESPECIFICADO | Salazar González, Bertha Cecilia | NO ESPECIFICADO | NO ESPECIFICADO | Villarreal Pérez, Jesús Zacarías | NO ESPECIFICADO | NO ESPECIFICADO |
|
Fecha del depósito: |
10 Jun 2013 17:49 |
Última modificación: |
25 Mayo 2020 18:29 |
URI: |
http://eprints.uanl.mx/id/eprint/3198 |
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