Impact of an exercise program on acylcarnitines in obesity: a prospective controlled study

Rodríguez Gutiérrez, René y Lavalle González, Fernando Javier y Martínez Garza, Laura E. y Landeros Olvera, Erick Alberto y López Alvarenga, Juan Carlos y Torres Sepúlveda, María Rosario y González González, José Gerardo y Mancillas Adame, Leonardo G. y Salazar González, Bertha Cecilia y Villarreal Pérez, Jesús Zacarías (2012) Impact of an exercise program on acylcarnitines in obesity: a prospective controlled study. Journal of the International Society of Sports Nutrition, 9 (22). pp. 1-8. ISSN 1550-2783

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Resumen

Background: Acylcarnitine (AC) transport dysfunction into the mitochondrial matrix is one of the pathophysiological mechanisms of type 2 diabetes mellitus (DM). The effect of an aerobic exercise (AE) program on this condition in obese subjects without DM is unclear. Methods: A prospective, randomized, longitudinal, interventional study in a University Research Center involved a 10-week AE program in 32 women without DM and a body mass index (BMI) greater than 27 kg/m2. (Cases n = 17; Controls n = 15). The primary objective was to evaluate the influence of a controlled AE program on beta-oxidation according to modifications in short, medium, and long-chain ACs. Secondary objectives were to define the behavior of amino acids, and the correlation between these modifications with metabolic and anthropometric markers. Results: The proportion of dropouts was 17% and 6% in controls and cases, respectively. In cases there was a significant reduction in total carnitine (30.40 [95% CI 28.2 to 35.6]) vs. (29.4 [CI 95% 25.1 to 31.7]) p=0.0008 and longchain AC C14 (0.06 [95% CI 0.05 to 0.08]) vs. (0.05 [95% CI 0.05 to 0.09]) p=0.005 and in C18 (0.31 [95% CI 0.27 to 0.45]) vs. (0.28 [95% CI 0.22 to 0.32]) p=0.03. Free fatty acid levels remained without change during the study in both groups. Conclusion: In conclusion, a controlled 10-week AE program improved beta-oxidation by reducing long-chain ACs. This finding highlights the importance that AE might have in avoiding or reverting lipotoxicity, and in consequence, improving insulin sensitivity and pancreatic beta cell functional reserve. Keywords: Beta-oxidation, Aerobic exercise, Diabetes mellitus, Overweight, Obesity, Lipotoxicity 3, 4, 2, 1, 1, 5 and 1

Tipo de elemento: Article
Palabras claves no controlados: Beta-oxidation, Aerobic exercise, Diabetes mellitus, Overweight, Obesity, Lipotoxicity
Materias: R Medicina > RT Enfermería
Divisiones: Enfermería
Usuario depositante: Admin Eprints
Creadores:
CreadorEmailORCID
Rodríguez Gutiérrez, RenéNO ESPECIFICADONO ESPECIFICADO
Lavalle González, Fernando Javierdrfernandolavalle@hotmail.comNO ESPECIFICADO
Martínez Garza, Laura E.NO ESPECIFICADONO ESPECIFICADO
Landeros Olvera, Erick AlbertoNO ESPECIFICADONO ESPECIFICADO
López Alvarenga, Juan CarlosNO ESPECIFICADONO ESPECIFICADO
Torres Sepúlveda, María RosarioNO ESPECIFICADONO ESPECIFICADO
González González, José GerardoNO ESPECIFICADONO ESPECIFICADO
Mancillas Adame, Leonardo G.NO ESPECIFICADONO ESPECIFICADO
Salazar González, Bertha CeciliaNO ESPECIFICADONO ESPECIFICADO
Villarreal Pérez, Jesús ZacaríasNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 10 Jun 2013 17:49
Última modificación: 25 Jun 2019 12:07
URI: http://eprints.uanl.mx/id/eprint/3198

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