Impact of an exercise program on acylcarnitines in obesity: a prospective controlled study
Rodríguez Gutiérrez, René y Lavalle González, Fernando Javier y Martínez Garza, Laura Elia y Landeros Olvera, Erick Alberto y López Alvarenga, Juan Carlos y Torres Sepúlveda, María del Rosario y González González, José Gerardo y Mancillas Adame, Leonardo G. y Salazar González, Bertha Cecilia y Villarreal Pérez, Jesús Zacarías
(2012)
Impact of an exercise program on acylcarnitines in obesity: a prospective controlled study.
Journal of the International Society of Sports Nutrition, 9 (22).
pp. 1-8.
ISSN 1550-2783
Resumen
Background: Acylcarnitine (AC) transport dysfunction into the mitochondrial matrix is one of the pathophysiological mechanisms of type 2 diabetes mellitus (DM). The effect of an aerobic exercise (AE) program on this condition in obese subjects without DM is unclear. Methods: A prospective, randomized, longitudinal, interventional study in a University Research Center involved a 10-week AE program in 32 women without DM and a body mass index (BMI) greater than 27 kg/m2. (Cases n = 17; Controls n = 15). The primary objective was to evaluate the influence of a controlled AE program on beta-oxidation according to modifications in short, medium, and long-chain ACs. Secondary objectives were to define the behavior of amino acids, and the correlation between these modifications with metabolic and anthropometric markers.
Results: The proportion of dropouts was 17% and 6% in controls and cases, respectively. In cases there was a significant reduction in total carnitine (30.40 [95% CI 28.2 to 35.6]) vs. (29.4 [CI 95% 25.1 to 31.7]) p=0.0008 and longchain AC C14 (0.06 [95% CI 0.05 to 0.08]) vs. (0.05 [95% CI 0.05 to 0.09]) p=0.005 and in C18 (0.31 [95% CI 0.27 to 0.45]) vs. (0.28 [95% CI 0.22 to 0.32]) p=0.03. Free fatty acid levels remained without change during the study in both groups.
Conclusion: In conclusion, a controlled 10-week AE program improved beta-oxidation by reducing long-chain ACs. This finding highlights the importance that AE might have in avoiding or reverting lipotoxicity, and in consequence, improving insulin sensitivity and pancreatic beta cell functional reserve.
Tipo de elemento: |
Article
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Palabras claves no controlados: |
Beta-oxidation, Aerobic exercise, Diabetes mellitus, Overweight, Obesity, Lipotoxicity |
Materias: |
R Medicina > RT Enfermería |
Divisiones: |
Enfermería |
Usuario depositante: |
Admin Eprints
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Creadores: |
Creador | Email | ORCID |
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Rodríguez Gutiérrez, René | NO ESPECIFICADO | NO ESPECIFICADO | Lavalle González, Fernando Javier | drfernandolavalle@hotmail.com | NO ESPECIFICADO | Martínez Garza, Laura Elia | NO ESPECIFICADO | NO ESPECIFICADO | Landeros Olvera, Erick Alberto | NO ESPECIFICADO | NO ESPECIFICADO | López Alvarenga, Juan Carlos | NO ESPECIFICADO | NO ESPECIFICADO | Torres Sepúlveda, María del Rosario | NO ESPECIFICADO | NO ESPECIFICADO | González González, José Gerardo | NO ESPECIFICADO | NO ESPECIFICADO | Mancillas Adame, Leonardo G. | NO ESPECIFICADO | NO ESPECIFICADO | Salazar González, Bertha Cecilia | NO ESPECIFICADO | NO ESPECIFICADO | Villarreal Pérez, Jesús Zacarías | NO ESPECIFICADO | NO ESPECIFICADO |
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Fecha del depósito: |
10 Jun 2013 17:49 |
Última modificación: |
10 Mayo 2023 15:57 |
URI: |
http://eprints.uanl.mx/id/eprint/3198 |
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