Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population

Cárdenas Estrada, Eloy y Oliveira, Lindomar Guimarães y Abad, Hernán Leonardo y Elayan, F. y Khalifa, N. y El-Husseini, Timour (2009) Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population. The Journal of International Medical Research, 37 (6). pp. 1937-1951. ISSN 1473-2300

Vista previa

Texto 2009-Celecoxib-V37-N06-DrECE.pdf - Versión Aceptada Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (212kB) | Vista previa

Resumen

Ankle sprains are common acute softtissue injuries. This 7-day open-label, multicentre, randomized study compared the efficacy and safety of celecoxib with non-selective non-steroidal antiinflammatory drugs (NSAIDs) in treating acute ankle sprain with moderate-tosevere ankle pain in 278 patients. Patients received either celecoxib (400 mg loading dose followed by 200 mg twice daily) or standard doses of non-selective NSAIDs. The primary endpoint was a change in the patient’s assessment of ankle pain on a 0 mm (no pain) – 100 mm (worst possible pain) visual analogue scale (VAS) at day 3 compared with baseline. From a baseline of 73 mm, mean VAS pain scores decreased to 29 and 32 mm in the celecoxib and non-selective NSAID groups, respectively. The lower limit of the 95% confidence interval for the treatment difference with regard to change from baseline was greater than the preestablished non-inferiority margin of –10 mm. Using an initial loading dose, celecoxib was at least as efficacious as non-selective NSAIDs in treating acute pain due to ankle sprain

Actions (login required)

Ver elemento