Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population

Cárdenas Estrada, Eloy y Oliveira, L. G. y Abad, H. L. y Elayan, F. y Khalifa, N. y El-Husseini, T. (2009) Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population. The Journal of International Medical Research, 37 (6). pp. 1937-1951. ISSN 1473-2300

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Resumen

Ankle sprains are common acute softtissue injuries. This 7-day open-label, multicentre, randomized study compared the efficacy and safety of celecoxib with non-selective non-steroidal antiinflammatory drugs (NSAIDs) in treating acute ankle sprain with moderate-tosevere ankle pain in 278 patients. Patients received either celecoxib (400 mg loading dose followed by 200 mg twice daily) or standard doses of non-selective NSAIDs. The primary endpoint was a change in the patient’s assessment of ankle pain on a 0 mm (no pain) – 100 mm (worst possible pain) visual analogue scale (VAS) at day 3 compared with baseline. From a baseline of 73 mm, mean VAS pain scores decreased to 29 and 32 mm in the celecoxib and non-selective NSAID groups, respectively. The lower limit of the 95% confidence interval for the treatment difference with regard to change from baseline was greater than the preestablished non-inferiority margin of –10 mm. Using an initial loading dose, celecoxib was at least as efficacious as non-selective NSAIDs in treating acute pain due to ankle sprain

Tipo de elemento: Article
Palabras claves no controlados: celecoxib; non-steroidal anti-inflammatory drugs (nsaids); non-selective nsaids; cyclo-oxygenase-2 (cox-2) selective nsaids; loading dose; ankle sprain; ankle pain
Materias: R Medicina > RC Medicina Interna, Psiquiatría, Neurología
R Medicina > RM Terapéutica, Farmacología
Divisiones: Organización Deportiva
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Cárdenas Estrada, EloyNO ESPECIFICADONO ESPECIFICADO
Oliveira, L. G.NO ESPECIFICADONO ESPECIFICADO
Abad, H. L.NO ESPECIFICADONO ESPECIFICADO
Elayan, F.NO ESPECIFICADONO ESPECIFICADO
Khalifa, N.NO ESPECIFICADONO ESPECIFICADO
El-Husseini, T.NO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 10 Mar 2015 20:43
Última modificación: 11 Mar 2015 21:26
URI: http://eprints.uanl.mx/id/eprint/4440

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