Detection of left ventricular hypertrophy by Tc-99 tetrofosmin gated-SPECT.

Peña Almaguer, Erasmo de la y Desai, Milind Y. y Mannting, Finn (2009) Detection of left ventricular hypertrophy by Tc-99 tetrofosmin gated-SPECT. Medicina Universitaria, 11 (42). pp. 29-35. ISSN 1665-5796 (Entregado)

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Introduction. Left ventricular hypertrophy (LVH) is a strong cardiovascular risk factor and an independent major cardiac risk factor for sudden cardiac death, myocardial infarction and stroke. The objective of this study was to determine the specificity, sensitivity, positive predictive value (PPV) Negative Predictive Value (NPV) and accuracy of a Tc-99 gated-SPECT method for detecting LVH. Methods: Patients referred for evaluation of known or suspected CAD, who underwent myocardial perfusion SPECT imaging with Tc-99 Tetrofosmin and who had also an echocardiogram performed within the previous 2 months were prospectively enrolled in the study. The group consisted of 52 patients, 25 men and 27 women, the mean age was 64.5 ± 12 yrs. Results: When the echocardiographic LVH was defined as a mean wall thickness VSTd + PWTd/2 ≥ 11mm, the SPECT method had aspecificity and sensitivity of 91% and 33% respectively, a PPV of 94%, a NPV of 48% and an accuracy of 58%. When the LVH was defined as a thickness to radius ratio (h/r) >0.45, the SPECT Method showed a specificity of 95%, sensitivity of 37% and a PPV of 97% and NPV of 54% with an accuracy of 62% . In Men, when the LVH criteria was a LV Mass >111 g/m2, the specificity and sensitivity for the SPECT method criteria was 100% and 20% respectively with a PPV, NPV and Accuracy of 100%, 45% and 48%. In Women, when LVH was defined as a LV Mass >106 g/m2, the SPECT method had a specificity of 91% and sensitivity of 44%, a PPV of 94%, and NPV and Accuracy of 42% and 63%. If the criteria was a LV Mass >125 g/m2, SPECT showed a specificity and sensitivity of 86% and 30% respectively and a PPV of 85% and a NPV of 64% with an Accuracy of 62 %.

Tipo de elemento: Article
Palabras claves no controlados: Left Ventricle, Hypertrophy, Tc-99 Tetrofosmin
Divisiones: Medicina
Usuario depositante: Lic. Josimar Pulido
Peña Almaguer, Erasmo de laerasmo@bwh.harvard.eduNO ESPECIFICADO
Fecha del depósito: 08 Dic 2015 02:09
Última modificación: 08 Dic 2015 02:09

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