Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females

Gutiérrez Muñoz, Mayra y Fajardo Araujo, Martha y González Pérez, Erika y Aguirre Arzola, Víctor Eustorgio y Solís Ortiz, Silvia (2018) Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females. Brain sciences, 8 (12). pp. 1-19. ISSN 2076-3425

Vista previa

Texto 42.pdf - Versión Publicada Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (795kB) | Vista previa

Resumen

Abstract: Polymorphisms of the estrogen receptor ESR1 and ESR2 genes have been linked with cognitivedeficitsandaffectivedisorders. Theeffectsofthesegeneticvariantsonemotionalprocessing infemaleswithlowestrogenlevelsarenotwellknown. TheaimwastoexploretheimpactoftheESR1 and ESR2 genes on the responses to the facial emotion recognition task in females. Postmenopausal healthy female volunteers were genotyped for the polymorphisms Xbal and PvuII of ESR1 and the polymorphism rs1256030 of ESR2. The effect of these polymorphisms on the response to the facial emotion recognition of the emotions happiness, sadness, disgust, anger, surprise, and fear was analyzed. Females carrying the P allele of the PvuII polymorphism or the X allele of the Xbal polymorphism of ESR1 easily recognized facial expressions of sadness that were more difficult for the women carrying the p allele or the x allele. They displayed higher accuracy, fast response time, more correct responses, and fewer omissions to complete the task, with a large effect size. Women carrying the ESR2 C allele of ESR2 showed a faster response time for recognizing facial expressionsofanger. ThesefindingslinkESR1andESR2polymorphismsinfacialemotionrecognition of negative emotions.

Actions (login required)

Ver elemento