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Replication of Integrative Data Analysis for Adipose Tissue Dysfunction, Low-Grade Inflammation, Postprandial Responses and OMICs Signatures in Symptom-Free Adults
Gallegos Cabriales, Esther Carlota y Rodríguez Ayala, Ernesto y Laviada Molina, Hugo A. y Nava González, Edna Judith y Salinas Osornio, Rocío A. y Orozco, Lorena y Leal Berumen, Irene y Castillo Pineda, Juan Carlos y González López, Laura y Escudero Lourdes, Claudia y Cornejo Barrera, Judith y Escalante Araiza, Fabiola y Huerta Ávila, Eira E. y Buenfil Rello, Fatima A. y Peschard, Vanessa Giselle y Silva, Eliud y Veloz Garza, Rosa A. y Martínez Hernández, Angélica y Barajas Olmos, Francisco M. y Molina Segui, Fernanda y Gonzalez Ramirez, Lucia y Arjona Villicaña, Ruy D. y Hernandez Escalante, Victor M. y Gaytan Saucedo, Janeth F. y Vaquera, Zoila y Acebo Martinez, Mónica Lucía y Murillo Ramirez, Areli y Diaz Tena, Sara P. y Figueroa Nuñez, Benigno y Valencia Rendón, Melesio E. y Garzon Zamora, Rafael y Viveros Paredes, Juan Manuel y Valdovinos Chávez, Salvador B. y Comuzzie, Anthony G. y Haack, Karin y Thorsell, Ashley A. y Han, Xianlin y Cole, Shelley A. y Bastarrachea, Raúl A. (2021) Replication of Integrative Data Analysis for Adipose Tissue Dysfunction, Low-Grade Inflammation, Postprandial Responses and OMICs Signatures in Symptom-Free Adults. Biology, 10 (12). pp. 1-20. ISSN 2079-7737
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Texto
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Resumen
We previously reported preliminary characterization of adipose tissue (AT) dysfunction through the adiponectin/leptin ratio (ALR) and fasting/postprandial (F/P) gene expression in subcutaneous (SQ) adipose tissue (AT) biopsies obtained from participants in the GEMM study, a precision medicine research project. Here we present integrative data replication of previous findings from an increased number of GEMM symptom-free (SF) adults (N = 124) to improve characterization of early biomarkers for cardiovascular (CV)/immunometabolic risk in SF adults with AT dysfunction. We achieved this goal by taking advantage of the rich set of GEMM F/P 5 h time course data and three tissue samples collected at the same time and frequency on each adult participant (F/P blood, biopsies of SQAT and skeletal muscle (SKM)). We classified them with the presence/absence of AT dysfunction: low (1) ALR. We also examined the presence of metabolically healthy (MH)/unhealthy (MUH) individuals through low-grade chronic subclinical inflammation (high sensitivity C-reactive protein (hsCRP)), whole body insulin sensitivity (Matsuda Index) and Metabolic Syndrome criteria in people with/without AT dysfunction. Molecular data directly measured from three tissues in a subset of participants allowed fine-scale multi-OMIC profiling of individual postprandial responses (RNA-seq in SKM and SQAT, miRNA from plasma exosomes and shotgun lipidomics in blood). Dynamic postprandial immunometabolic molecular endophenotypes were obtained to move towards a personalized, patient-defined medicine. This study offers an example of integrative translational research, which applies bench-to-bedside research to clinical medicine. Our F/P study design has the potential to characterize CV/immunometabolic early risk detection in support of precision medicine and discovery in SF individuals.
| Tipo de elemento: | Article | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Palabras claves no controlados: | fenotipo metabólicamente sano/no sano, disfunción del tejido adiposo, respuesta inflamatoria posprandial, inflamación subclínica crónica de bajo grado, biopsias de tejido adiposo y muscular, Firmas moleculares OMIC, voluntarios sin síntomas. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Materias: | Q Ciencia > QH Historia Natural, Biología | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Divisiones: | Enfermería | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Usuario depositante: | Editor Repositorio | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Fecha del depósito: | 29 Jun 2022 20:19 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Última modificación: | 04 Mar 2024 16:08 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| URI: | http://eprints.uanl.mx/id/eprint/23501 |
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