Genetic structure of Mexican Mestizos with type 2 diabetes mellitus based on three {STR} loci

Cerda Flores, Ricardo M. y Rivera Prieto, Roxana A. y Pereyra Alférez, Benito y Calderón Garcidueñas, Ana L. y Barrera Saldana, Hugo A. y Gallardo Blanco, Hugo L. y Ortiz López, Rocío y Flores Peña, Yolanda y Cárdenas Villarreal, Velia M. y Rivas, Fernando y Figueroa, Andres y Kshatriya, Gautam (2013) Genetic structure of Mexican Mestizos with type 2 diabetes mellitus based on three {STR} loci. Gene, 525 (1). pp. 41-46. ISSN 03781119

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URL o página oficial: https://linkinghub.elsevier.com/retrieve/pii/S0378...

Resumen

Background: The aims of this population genetics study were: 1) to ascertain whether Mexicans with type 2 diabetes mellitus ({DM}) were genetically homogeneous and 2) to compare the genetic structure of this selected population with the previously reported data of four random populations (Nuevo Leon, Hispanics, Chihuahua, and Central Region of Mexico). Methods: A sample of 103 unrelated individuals with {DM} and whose 4 grandparents were born in five zones of Mexico was interviewed in 32 Medical Units in the Mexican Institute of Social Security ({IMSS}). The non-coding {STRs} D16S539, D7S820, and D13S317 were analyzed. Results: Genotype distribution was in agreement with Hardy-Weinberg expectations for all three markers. Allele frequencies were found to be similar between the selected population and the four random populations. Gene diversity analysis suggested that more than 99.57\% of the total gene diversity could be attributed to variation between individuals within the population and 0.43\% between the populations. Conclusions: According to the present and previous studies using molecular and non-molecular nuclear {DNA} markers not associated with any disease, the Mexican Mestizo population is found to be genetically homogeneous and therefore the genetic causes of {DM} are less heterogeneous, thereby simplifying genetic epidemiological studies as has been found in a previous study with the same design in Mexican women with breast cancer.

Tipo de elemento:

Article

Palabras claves no controlados:

Diabetes mellitus tipo 2, frecuencia genética; Loci genéticos; Genética; Población; Genotipo; Mexicoamericanos; Repeticiones de microsatélites; Análisis de componentes principales

Materias:

CONACYT > Medicina y Ciencias de la Salud

Divisiones:

Enfermería

Usuario depositante:

Dr.C. Hugo Gallardo Blanco

Creadores:

Creador	Email	ORCID
Cerda Flores, Ricardo M.	NO ESPECIFICADO	NO ESPECIFICADO
Rivera Prieto, Roxana A.	NO ESPECIFICADO	NO ESPECIFICADO
Pereyra Alférez, Benito	NO ESPECIFICADO	NO ESPECIFICADO
Calderón Garcidueñas, Ana L.	NO ESPECIFICADO	NO ESPECIFICADO
Barrera Saldana, Hugo A.	NO ESPECIFICADO	NO ESPECIFICADO
Gallardo Blanco, Hugo L.	hugo.gallardobl@uanl.edu.mx	orcid.org/0000-0002-7816-4967
Ortiz López, Rocío	NO ESPECIFICADO	NO ESPECIFICADO
Flores Peña, Yolanda	NO ESPECIFICADO	NO ESPECIFICADO
Cárdenas Villarreal, Velia M.	NO ESPECIFICADO	NO ESPECIFICADO
Rivas, Fernando	NO ESPECIFICADO	NO ESPECIFICADO
Figueroa, Andres	NO ESPECIFICADO	NO ESPECIFICADO
Kshatriya, Gautam	NO ESPECIFICADO	NO ESPECIFICADO