Uridine 5' diphospho glucronosyltrasferase: Its role in pharmacogenomics and human disease (Review)

Sánchez Domínguez, Celia Nohemí y Gallardo Blanco, Hugo Leonid y Salinas Santander, Mauricio y Ortiz López, Rocío (2018) Uridine 5' diphospho glucronosyltrasferase: Its role in pharmacogenomics and human disease (Review). Experimental and Therapeutic Medicine. ISSN 1792-0981, 1792-1015

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Resumen

Biotransformation is an enzyme catalyzed process in which the body converts endogenous compounds, xenobiotics and toxic substances into harmless or easily excreted metabolites. The biotransformation reactions are classified as phase I and {II} reactions. Uridine 5' diphospho ({UDP}) glucuronosyltransferases ({UGTs}) are a superfamily of phase {II} enzymes which have roles in the conjugation of xenobiotics or endogenous compounds, including drugs and bilirubin, with glucuronic acid to make them easier to excrete. The method the human body uses to achieve glucuronidation may be affected by a large interindividual variation due to changes in the sequences of the genes encoding these enzymes. In the last five years, the study of the genetic variants of the {UGTs} at a molecular level has become important due to its association with several diseases and the ability to predict adverse events due to drug metabolism. In the present review, the structure and the prominent genetic variants of the {UGT}1A subfamily and their metabolic and clinical implications are described.

Tipo de elemento:	Article
Palabras claves no controlados:	UGT1A1*1, UGT1A1*28, Pharmacogenomics, Uridine 5'-diphospho-glucuronosyltransferases
Materias:	CONACYT > Biología y Química CONACYT > Medicina y Ciencias de la Salud
Divisiones:	Medicina > Maestría en Ciencias con Orientación en Biología Molecular e Ingeniería Genética
Usuario depositante:	Dr.C. Hugo Gallardo Blanco
Creadores:	Creador Email ORCID Sánchez Domínguez, Celia Nohemí celia.sanchezdm@uanl.edu.mx orcid.org/0000-0002-3444-9565 Gallardo Blanco, Hugo Leonid hugo.gallardobl@uanl.edu.mx orcid.org/0000-0002-7816-4967 Salinas Santander, Mauricio NO ESPECIFICADO NO ESPECIFICADO Ortiz López, Rocío NO ESPECIFICADO NO ESPECIFICADO
Fecha del depósito:	24 Sep 2026 16:08
Última modificación:	24 Sep 2026 16:08
URI:	http://eprints.uanl.mx/id/eprint/31443

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