In vitro anti-canine distemper virus activity of fucoidan extracted from the brown alga Cladosiphon okamuranus

Trejo Ávila, Laura y Morales Martinez, ME y Ricque Marie, Denis y Cruz Suárez, Lucía Elizabeth y Zapata Benavides, Pablo y Morán Santibáñez, Karla Selene y Rodríguez Padilla, Cristina (2014) In vitro anti-canine distemper virus activity of fucoidan extracted from the brown alga Cladosiphon okamuranus. Virus disease, 25. pp. 474-480. ISSN 1201-9712

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Canine distemper virus (CDV) is a morbillivirus related to measles virus that infects dogs and other carnivores. CDV has a significant global impact on animal health; however, there is no current antiviral treatment for CDV infection. In recent years, it has been demonstrated that sulfated polysaccharides exhibit antiviral properties both in vivo and in vitro, despite their low cytotoxicity to host cells. Fucoidan is a sulfated polysaccharide found in the cell wall matrix of brown algae. In this study, we evaluated in vitro anti-CDV activity of fucoidan, which was derived from Cladosiphon okamuranus. Fucoidan actively inhibited CDV replication in Vero cells at a 50% inhibitory concentration (IC50) of 0.1 lg/ml. The derived selectivity index (SI50) was[20,000. This polysaccharide likely inhibits viral infection by interference in the early steps and by inhibiting CDV-mediated cell fusion. Fucoidan may be useful in development of pharmacological strategies to treat and control CDV infection.

Tipo de elemento: Article
Palabras claves no controlados: Fucoidan; CDV; Antiviral; Cladosiphon; Okamuranus; Morbillivirus In
Materias: S Agricultura > SH Acuacultura / Pesca
Divisiones: Ciencias Biológicas
Usuario depositante: Dra. Lucia Elizabeth Cruz Suarez
Creadores:
CreadorEmailORCID
Trejo Ávila, LauraNO ESPECIFICADONO ESPECIFICADO
Morales Martinez, MENO ESPECIFICADONO ESPECIFICADO
Ricque Marie, DenisNO ESPECIFICADONO ESPECIFICADO
Cruz Suárez, Lucía ElizabethNO ESPECIFICADONO ESPECIFICADO
Zapata Benavides, PabloNO ESPECIFICADONO ESPECIFICADO
Morán Santibáñez, Karla SeleneNO ESPECIFICADONO ESPECIFICADO
Rodríguez Padilla, CristinaNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 05 Sep 2016 20:38
Última modificación: 08 Dic 2016 14:10
URI: http://eprints.uanl.mx/id/eprint/11163

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