Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq

Martínez Jacobo, Lizeth Alejandra y Ancer Arellano, Claudia I. y Ortiz López, Rocío y Salinas Santander, Mauricio Andrés y Villarreal Villarreal, César Daniel y Ancer Rodríguez, Jesús y Camacho Zamora, Bianka Dianey y Zomosa Signoret, Viviana Chantal y Medina de la Garza, Carlos Eduardo y Ocampo Candiani, Jorge y Rojas Martínez, Augusto (2017) Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq. Skin Appendage Disorders, 4 (4). pp. 268-273. ISSN 2296-9195

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Resumen

Abstract Androgenetic alopecia (AGA) or male pattern baldness is the most common form of hair loss in humans. Despite being a very frequent dermatological entity, molecular pathophysiology remains unclear. Several authors relate the presentation of AGA with a premature apoptotic process during the anagen phase and with an inflammatory microenvironment in the hair follicle. We evaluated a panel of 30 genes associated with inflammation and apoptosis in 5 AGA patients by targeted RNA-Seq. WNT7A gene was highly expressed in patients in stages 3V to 5 on the Hamilton-Norwood scale compared to patients with 5A stage. CASP7 and TNF genes were overexpressed in stages 3V and 4 compared to stages 5 and 5A. Overexpression of these genes detected only at early stages of AGA proves the role of WNT pathway, apoptosis, and inflammation in the development of this disorder.

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