Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq

Martinez Jacobo, Lizeth y Ancer Arellano, Claudia I. y Ortiz López, Rocío y Salinas Santander, Mauricio y Villarreal Villarreal, Cesar Daniel y Ancer Rodríguez, Jesús y Camacho Zamora, Bianka y Zomosa Signoret, Viviana y Medina De la Garza, Carlos E. y Ocampo Candiani, Jorge y Rojas Martinez, Augusto (2017) Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq. Skin Appendage Disorders, 4 (4). pp. 268-273. ISSN 2296-9195

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URL o página oficial: http://doi.org/10.1159/000484530

Resumen

Abstract Androgenetic alopecia (AGA) or male pattern baldness is the most common form of hair loss in humans. Despite being a very frequent dermatological entity, molecular pathophysiology remains unclear. Several authors relate the presentation of AGA with a premature apoptotic process during the anagen phase and with an inflammatory microenvironment in the hair follicle. We evaluated a panel of 30 genes associated with inflammation and apoptosis in 5 AGA patients by targeted RNA-Seq. WNT7A gene was highly expressed in patients in stages 3V to 5 on the Hamilton-Norwood scale compared to patients with 5A stage. CASP7 and TNF genes were overexpressed in stages 3V and 4 compared to stages 5 and 5A. Overexpression of these genes detected only at early stages of AGA proves the role of WNT pathway, apoptosis, and inflammation in the development of this disorder.

Tipo de elemento: Article
Materias: R Medicina > RC Medicina Interna, Psiquiatría, Neurología
R Medicina > RL Dermatología
R Medicina > RM Terapéutica, Farmacología
Divisiones: Medicina
Usuario depositante: Lic. Josimar Pulido
Creadores:
CreadorEmailORCID
Martinez Jacobo, LizethNO ESPECIFICADONO ESPECIFICADO
Ancer Arellano, Claudia I.NO ESPECIFICADONO ESPECIFICADO
Ortiz López, RocíoNO ESPECIFICADONO ESPECIFICADO
Salinas Santander, MauricioNO ESPECIFICADONO ESPECIFICADO
Villarreal Villarreal, Cesar DanielNO ESPECIFICADONO ESPECIFICADO
Ancer Rodríguez, JesúsNO ESPECIFICADONO ESPECIFICADO
Camacho Zamora, BiankaNO ESPECIFICADONO ESPECIFICADO
Zomosa Signoret, VivianaNO ESPECIFICADONO ESPECIFICADO
Medina De la Garza, Carlos E.NO ESPECIFICADONO ESPECIFICADO
Ocampo Candiani, JorgeNO ESPECIFICADONO ESPECIFICADO
Rojas Martinez, AugustoNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 25 Jun 2020 16:12
Última modificación: 25 Jun 2020 16:12
URI: http://eprints.uanl.mx/id/eprint/16088

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