Furanocoumarins from Ruta chalepensis with Amebicide Activity
Bazaldúa Rodríguez, Aldo Fabio y Quintanilla Licea, Ramiro y Verde Star, María Julia y Hernández García, Magda Elizabeth y Vargas Villarreal, Javier y Garza González, Jesús Norberto (2021) Furanocoumarins from Ruta chalepensis with Amebicide Activity. Molecules, 26 (12). pp. 1-11. ISSN 1420-3049
|
Texto
23626.pdf - Versión Publicada Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (8MB) | Vista previa |
Resumen
Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries. In addition, parasite resistance to conventional medicinal treatment has increased in recent years. Traditional medicine around the world represents a valuable source of alternative treatment for many parasite diseases. In a previous paper, we communicated about the antiprotozoal activity in vitro of the methanolic (MeOH) extract of Ruta chalepensis (Rutaceae) against E. histolytica. The plant is extensively employed in Mexican traditional medicine. The following workup of the MeOH extract of R. chalepensis afforded the furocoumarins rutamarin (1) and chalepin (2), which showed high antiprotozoal activity on Entamoeba histolytica trophozoites employing in vitro tests (IC50 values of 6.52 and 28.95 µg/mL, respectively). Therefore, we offer a full scientific report about the bioguided isolation and the amebicide activity of chalepin and rutamarin.
Tipo de elemento: | Article | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Palabras claves no controlados: | enfermedades parasitarias, amebiasis, medicina tradicional mexicana, aislamiento bioguiado, productos naturales, agentes antiprotozoarios | |||||||||||||||||||||
Materias: | Q Ciencia > QP Fisiología | |||||||||||||||||||||
Divisiones: | Ciencias Biológicas | |||||||||||||||||||||
Usuario depositante: | Editor Repositorio | |||||||||||||||||||||
Creadores: |
|
|||||||||||||||||||||
Fecha del depósito: | 20 Ago 2022 12:57 | |||||||||||||||||||||
Última modificación: | 20 Ago 2022 12:57 | |||||||||||||||||||||
URI: | http://eprints.uanl.mx/id/eprint/23626 |
Actions (login required)
Ver elemento |