Furanocoumarins from Ruta chalepensis with Amebicide Activity

Bazaldúa Rodríguez, Aldo Fabio y Quintanilla Licea, Ramiro y Verde Star, María Julia y Hernández García, Magda Elizabeth y Vargas Villarreal, Javier y Garza González, Jesús Norberto (2021) Furanocoumarins from Ruta chalepensis with Amebicide Activity. Molecules, 26 (12). pp. 1-11. ISSN 1420-3049

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Resumen

Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries. In addition, parasite resistance to conventional medicinal treatment has increased in recent years. Traditional medicine around the world represents a valuable source of alternative treatment for many parasite diseases. In a previous paper, we communicated about the antiprotozoal activity in vitro of the methanolic (MeOH) extract of Ruta chalepensis (Rutaceae) against E. histolytica. The plant is extensively employed in Mexican traditional medicine. The following workup of the MeOH extract of R. chalepensis afforded the furocoumarins rutamarin (1) and chalepin (2), which showed high antiprotozoal activity on Entamoeba histolytica trophozoites employing in vitro tests (IC50 values of 6.52 and 28.95 µg/mL, respectively). Therefore, we offer a full scientific report about the bioguided isolation and the amebicide activity of chalepin and rutamarin.

Tipo de elemento: Article
Palabras claves no controlados: enfermedades parasitarias, amebiasis, medicina tradicional mexicana, aislamiento bioguiado, productos naturales, agentes antiprotozoarios
Materias: Q Ciencia > QP Fisiología
Divisiones: Ciencias Biológicas
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
Bazaldúa Rodríguez, Aldo FabioNO ESPECIFICADONO ESPECIFICADO
Quintanilla Licea, Ramiroramiro.quintanillalc@uanl.edu.mxorcid.org/0000-0002-4379-6913
Verde Star, María JuliaNO ESPECIFICADONO ESPECIFICADO
Hernández García, Magda ElizabethNO ESPECIFICADONO ESPECIFICADO
Vargas Villarreal, JavierNO ESPECIFICADONO ESPECIFICADO
Garza González, Jesús NorbertoNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 20 Ago 2022 12:57
Última modificación: 20 Ago 2022 12:57
URI: http://eprints.uanl.mx/id/eprint/23626

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