Furanocoumarins from Ruta chalepensis with Amebicide Activity

Bazaldúa Rodríguez, Aldo Fabio y Quintanilla Licea, Ramiro y Verde Star, María Julia y Hernández García, Magda Elizabeth y Vargas Villarreal, Javier y Garza González, Jesús Norberto (2021) Furanocoumarins from Ruta chalepensis with Amebicide Activity. Molecules, 26 (12). pp. 1-11. ISSN 1420-3049

Vista previa

Texto
23626.pdf - Versión Publicada
Available under License Creative Commons Attribution Non-commercial No Derivatives.
Download (8MB) | Vista previa

URL o página oficial: http://doi.org/10.3390/molecules26123684

Resumen

Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries. In addition, parasite resistance to conventional medicinal treatment has increased in recent years. Traditional medicine around the world represents a valuable source of alternative treatment for many parasite diseases. In a previous paper, we communicated about the antiprotozoal activity in vitro of the methanolic (MeOH) extract of Ruta chalepensis (Rutaceae) against E. histolytica. The plant is extensively employed in Mexican traditional medicine. The following workup of the MeOH extract of R. chalepensis afforded the furocoumarins rutamarin (1) and chalepin (2), which showed high antiprotozoal activity on Entamoeba histolytica trophozoites employing in vitro tests (IC50 values of 6.52 and 28.95 µg/mL, respectively). Therefore, we offer a full scientific report about the bioguided isolation and the amebicide activity of chalepin and rutamarin.

Tipo de elemento:

Article

Palabras claves no controlados:

enfermedades parasitarias, amebiasis, medicina tradicional mexicana, aislamiento bioguiado, productos naturales, agentes antiprotozoarios

Materias:

Q Ciencia > QP Fisiología

Divisiones:

Ciencias Biológicas

Usuario depositante:

Editor Repositorio

Creadores:

Creador	Email	ORCID
Bazaldúa Rodríguez, Aldo Fabio	NO ESPECIFICADO	NO ESPECIFICADO
Quintanilla Licea, Ramiro	ramiro.quintanillalc@uanl.edu.mx	orcid.org/0000-0002-4379-6913
Verde Star, María Julia	NO ESPECIFICADO	NO ESPECIFICADO
Hernández García, Magda Elizabeth	NO ESPECIFICADO	NO ESPECIFICADO
Vargas Villarreal, Javier	NO ESPECIFICADO	NO ESPECIFICADO
Garza González, Jesús Norberto	NO ESPECIFICADO	NO ESPECIFICADO