Mean platelet volume is decreased in adults with active lupus disease
Delgado García, Guillermo Rubén y Galarza Delgado, Dionicio Ángel y Colunga Pedraza, Iris Jazmín y Borjas Almaguer, Omar David y Mandujano Cruz, Ilse y Benavides Salgado, Daniel Eduardo y Martínez Granados, Rolando Jacob y Atilano Díaz, Alexandro (2016) Mean platelet volume is decreased in adults with active lupus disease. Revista Brasileira de Reumatologia, 56 (6). pp. 504-508. ISSN 22555021
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Resumen
Background: Only a few biomarkers are available for assessing disease activity in systemic lupus erythematosus (SLE). Mean platelet volume (MPV) has been recently studied as an inflammatory biomarker. It is currently unclear whether MPV may also play a role as a biomarker of disease activity in adult patients with SLE. Objective: We investigated the association between MPV and disease activity in adult patients with SLE. Methods: In this retrospective study, we compared two groups of adult patients divided according to disease activity (36 per group). Subjects were age- and gender-matched. Results: MPV was significantly decreased with respect to those of inactive patients (7.16 ± 1.39 vs. 8.16 ± 1.50, p = 0.005). At a cutoff level of 8.32 fL, MPV has a sensitivity of 86% and a specificity of 41% for the detection of disease activity. A modest positive correlation was found between MPV and albumin (r = 0.407, p = 0.001), which in turn is inversely associated with disease activity. Conclusions: In summary, MPV is decreased in adult patients with active lupus disease, and positively correlated with albumin, another biomarker of disease activity. Prospective studies are needed to evaluate the prognostic value of this biomarker.
Tipo de elemento: | Article | |||||||||||||||||||||||||||
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Palabras claves no controlados: | Lupus eritematoso sistémico; Volumen plaquetario medio; Actividad de la enfermedad; Inflamación; Marcadores biológicos; Albúmina sérica. | |||||||||||||||||||||||||||
Materias: | R Medicina > RC Medicina Interna, Psiquiatría, Neurología | |||||||||||||||||||||||||||
Divisiones: | Medicina | |||||||||||||||||||||||||||
Usuario depositante: | Editor Repositorio | |||||||||||||||||||||||||||
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Fecha del depósito: | 30 Jul 2024 17:35 | |||||||||||||||||||||||||||
Última modificación: | 30 Jul 2024 17:35 | |||||||||||||||||||||||||||
URI: | http://eprints.uanl.mx/id/eprint/27794 |
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