Mean platelet volume is decreased in adults with active lupus disease

Delgado García, Guillermo Rubén y Galarza Delgado, Dionicio Ángel y Colunga Pedraza, Iris Jazmín y Borjas Almaguer, Omar David y Mandujano Cruz, Ilse y Benavides Salgado, Daniel Eduardo y Martínez Granados, Rolando Jacob y Atilano Díaz, Alexandro (2016) Mean platelet volume is decreased in adults with active lupus disease. Revista Brasileira de Reumatologia, 56 (6). pp. 504-508. ISSN 22555021

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Resumen

Background: Only a few biomarkers are available for assessing disease activity in systemic lupus erythematosus (SLE). Mean platelet volume (MPV) has been recently studied as an inflammatory biomarker. It is currently unclear whether MPV may also play a role as a biomarker of disease activity in adult patients with SLE. Objective: We investigated the association between MPV and disease activity in adult patients with SLE. Methods: In this retrospective study, we compared two groups of adult patients divided according to disease activity (36 per group). Subjects were age- and gender-matched. Results: MPV was significantly decreased with respect to those of inactive patients (7.16 ± 1.39 vs. 8.16 ± 1.50, p = 0.005). At a cutoff level of 8.32 fL, MPV has a sensitivity of 86% and a specificity of 41% for the detection of disease activity. A modest positive correlation was found between MPV and albumin (r = 0.407, p = 0.001), which in turn is inversely associated with disease activity. Conclusions: In summary, MPV is decreased in adult patients with active lupus disease, and positively correlated with albumin, another biomarker of disease activity. Prospective studies are needed to evaluate the prognostic value of this biomarker.

Tipo de elemento:

Article

Palabras claves no controlados:

Lupus eritematoso sistémico; Volumen plaquetario medio; Actividad de la enfermedad; Inflamación; Marcadores biológicos; Albúmina sérica.

Materias:

R Medicina > RC Medicina Interna, Psiquiatría, Neurología

Divisiones:

Medicina

Usuario depositante:

Editor Repositorio

Creadores:

Creador	Email	ORCID
Delgado García, Guillermo Rubén	NO ESPECIFICADO	NO ESPECIFICADO
Galarza Delgado, Dionicio Ángel	dgalarza@medicinauanl.mx	orcid.org/0000-0001-9714-2109
Colunga Pedraza, Iris Jazmín	NO ESPECIFICADO	NO ESPECIFICADO
Borjas Almaguer, Omar David	NO ESPECIFICADO	NO ESPECIFICADO
Mandujano Cruz, Ilse	NO ESPECIFICADO	NO ESPECIFICADO
Benavides Salgado, Daniel Eduardo	daniel-benavides@live.com	NO ESPECIFICADO
Martínez Granados, Rolando Jacob	rolando.martinezgd@uanl.edu.mx	orcid.org/0000-0002-7065-9463
Atilano Díaz, Alexandro	alexandroad@hotmail.com	NO ESPECIFICADO