Mild cognitive impairment

Isordia Martínez, Javier y Góngora Rivera, Juan Fernando y Leal Bailey, H. y Ortiz Jiménez, Xóchitl A. (2014) Mild cognitive impairment. Medicina universitaria, 16 (62). pp. 28-36. ISSN 1665-5796

Vista previa

Texto X1665579614283699_S300_en.pdf - Versión Publicada Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (256kB) | Vista previa

Resumen

Abstract Mild Cognitive Impairment (MCI) is a disease between normal cognitive ageing and dementia. In recent years the term MCI has been recognized as a pre-dementia state, raising an important subject for investigation in the prevention of dementia. There are various terms related to pre-dementia MCI, such as isolated memory complaint and pre-Alzheimer’s disease; most of them do not comprise all the areas related to MCI. A central cholinergic deficit is present in amnestic MCI with neuronal loss in the Meynert basal nucleus. It is estimated that the rate of progression to dementia is about 10% every year. The prevalence of MCI is 10%-11% and the risk of progression to dementia is about 5%-16%. The continual development of pharmacologic approaches to modify and delay the natural history of progression of the disease motivates a great interest in an earlier diagnosis.

Actions (login required)

Ver elemento