Comparison of the eficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphineinduced pruritus

Cruz Ferretti, Ulises y Llanes Garza, Hilda Alicia y López Cabrera, Norma Guadalupe y Espinosa Galindo, Ana María y Palacios Ríos, Dionicio y Cano García, Martha Araceli y Estrada Solís, Yesenia Nohemí (2014) Comparison of the eficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphineinduced pruritus. Medicina universitaria, 16 (64). pp. 107-111. ISSN 1665-5796

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Resumen

Objective: To compare the eficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphine-induced pruritus, in patients at the “Dr. José Eleuterio González” University Hospital from September 2012 to August 2013. Material and methods: A controlled, prospective, randomized study of 28 patients (14 per group) receiving neuraxial morphine analgesia was conducted, which was registered and approved by the ethics Committee of the Institution and patients agreed to participate in the study under informed consent. The results were segmented and contrasted (according to drug) by hypothesis testing; the association was determined by X2 with a 95% conidence interval (CI). Results: Pruritus was effectively resolved in both groups and no signiicant difference was found in the rest of the variables. An increase in the visual analogue scale (eVA) was observed at 6 and 12 hours for the ondansetron group, which was statistically signiicant (p≤0.05), however both groups had an eVA of less than 3. Conclusions: When comparing the eficacy and safety of ondansetron 4 mg vs. nalbuphine 4 mg for the treatment of neuraxial morphine induced pruritus, the only signiicant difference found was the mean eVA at 6 and 12 hours, favoring the ondansetron group. However, both groups scored less than 3 on the eVA. Therefore, we consider that both treatments are effective and safe in the treatment of pruritus caused by neuraxial morphine.

Tipo de elemento: Article
Palabras claves no controlados: Pruritus; Ondansetron; Morphine; Nalbuphine; Neuraxial analgesia; Mexico
Materias: R Medicina > R Medicina en General
Divisiones: Medicina
Usuario depositante: Editor Repositorio
Creadores:
CreadorEmailORCID
Cruz Ferretti, UlisesNO ESPECIFICADONO ESPECIFICADO
Llanes Garza, Hilda AliciaNO ESPECIFICADONO ESPECIFICADO
López Cabrera, Norma GuadalupeNO ESPECIFICADONO ESPECIFICADO
Espinosa Galindo, Ana MaríaNO ESPECIFICADONO ESPECIFICADO
Palacios Ríos, DionicioNO ESPECIFICADONO ESPECIFICADO
Cano García, Martha AraceliNO ESPECIFICADONO ESPECIFICADO
Estrada Solís, Yesenia NohemíNO ESPECIFICADONO ESPECIFICADO
Fecha del depósito: 21 Oct 2016 20:53
Última modificación: 18 Mayo 2021 17:43
URI: http://eprints.uanl.mx/id/eprint/11456

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