Synergistic Effects of Sulfated Polysaccharides from Mexican Seaweeds against Measles Virus

Morán Santibáñez, Karla Selene y Cruz Suárez, Lucía Elizabeth y Ricque Marie, Denis y Robledo, Daniel y Freile Pelegrín, Yolanda y Peña Hernández, Mario A. y Rodríguez Padilla, Cristina y Trejo Ávila, Laura M. (2016) Synergistic Effects of Sulfated Polysaccharides from Mexican Seaweeds against Measles Virus. BioMed Research International, 2016. pp. 1-11. ISSN 2314-6133

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Resumen

Sulfated polysaccharides (SPs) extracted from five seaweed samples collected or cultivated in Mexico (Macrocystis pyrifera, Eisenia arborea, Pelvetia compressa, Ulva intestinalis, and Solieria filiformis) were tested in this study in order to evaluate their effect on measles virus in vitro. All polysaccharides showed antiviral activity (as measured by the reduction of syncytia formation) and low cytotoxicity (MTT assay) at inhibitory concentrations. SPs from Eisenia arborea and Solieria filiformis showed the highest antiviral activities (confirmed by qPCR) and were selected to determine their combined effect. Their synergistic effect was observed at low concentrations (0.0274

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