Differences in the presentation and treatment of primary liver tumors at a hepatology center and an oncology center

Rojas Pintor, K.P. y Arizmendi Villarreal, M.A. y Aparicio Salas, J.E. y Moreno Peña, Diana Patricia y Hernández Barajas, David y Cordero Pérez, Paula y Muñoz Espinosa, Linda Elsa (2021) Differences in the presentation and treatment of primary liver tumors at a hepatology center and an oncology center. Revista de gastroenterología de México, 86 (4). pp. 370-377. ISSN 0375-0906

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Resumen

Introduction and aims: Primary liver cancer is a public health problem in Mexico and the world. Liver transplantation (LT) is the ideal treatment for early hepatocellular carcinoma (HCC). Our aim was to evaluate the characteristics of patients with HCC and cholangiocarcinoma (CC) at two centers and identify transplantation candidates. Materials and methods: A retrospective observational study was conducted at the Hepatology Center (HC) and the University Center Against Cancer (UCAC), within the time frame of 2012---2018. HCC or intrahepatic CC was confirmed in 109 patients. Staging classifications, transplant selection models, and a predictive model for post-LT recurrence were applied to the HCC patients. Results: Of the total population, 93% (n = 102) presented with cirrhosis, 86% (n = 94) had HCC (HC: 58%, UCAC: 42%), and 14% (n = 15) had intrahepatic CC (HC: 40%, UCAC: 60%). Of the HC patients with HCC, Okuda I---II, BCLC A---B, and AFP levels <100 ng/m predominated, whereas Okuda II-III, BCLC C-D, and AFP levels >1000 ng/mL predominated in the UCAC patients. Half of the HC population with HCC met the criteria for LT, in contrast to 23% of the UCAC patients. Fifteen patients were evaluated for LT, and at present, six have undergone transplantation.

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