In Vitro Evaluation of Colloidal Silver on Immune Function: Antilymphoproliferative Activity

Franco Molina, Moisés Armides y Mendoza Gamboa, Edgar y Zárate Triviño, Diana Ginette y Coronado Cerda, Erika Evangelina y Alcocer González, Juan Manuel y Reséndez Pérez, Diana y Rodríguez Salazar, María del Carmen y Rivera Morales, Lydia Guadalupe y Tamez Guerra, Reyes Silvestre y Rodríguez Padilla, Cristina (2016) In Vitro Evaluation of Colloidal Silver on Immune Function: Antilymphoproliferative Activity. Journal of Nanomaterials, 2016. pp. 1-8. ISSN 1687-4110

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Resumen

Colloidal silver (AgC) is currently used by humans and it can be internalized through inhalation, injection, ingestion, and dermal contact. However, there is limited information about immunological activity; more investigations using colloidal silver are needed. In the present study, the effects of AgC (17.5 ng/mL) on immunological parameters (proliferation and immunophenotyping) using human peripheral blood mononuclear cells (PBMC) and macrophages (phagocytosis) and cytotoxicity on leukemia and lymphoma cancer cell lines (1.75 to 17.5 ng/mL) were investigated. AgC was observed to significantly (p<0.05) decrease interleukin-2 (IL-2) production and proliferation induced by phytohemagglutinin or concanavalin A in PBMC without affecting its cell viability but with cytotoxic effect on cancer cells. IL-2, IL-4, IL-6, IL-10, INF-γ, and IL-17A cytokines production and CD3+, CD3−CD19+, CD3+CD4+, CD3+CD8+, and CD16+CD56+ PBMC phenotypes were not affected by AgC. The present study demonstrates that colloidal silver is harmless and nontoxic to the immune system cells and its ability to interfere with the immune response by decreasing cell proliferation when stimulated with mitogens demonstrated the antilymphoproliferative potential of AgC.

Tipo de elemento:	Article
Materias:	R Medicina > R Medicina en General
Divisiones:	Ciencias Biológicas
Usuario depositante:	Editor Repositorio
Creadores:	Creador Email ORCID Franco Molina, Moisés Armides NO ESPECIFICADO NO ESPECIFICADO Mendoza Gamboa, Edgar edgar.mendozagm@uanl.edu.mx orcid.org/0000-0002-0827-5717 Zárate Triviño, Diana Ginette NO ESPECIFICADO NO ESPECIFICADO Coronado Cerda, Erika Evangelina NO ESPECIFICADO NO ESPECIFICADO Alcocer González, Juan Manuel NO ESPECIFICADO NO ESPECIFICADO Reséndez Pérez, Diana NO ESPECIFICADO NO ESPECIFICADO Rodríguez Salazar, María del Carmen NO ESPECIFICADO NO ESPECIFICADO Rivera Morales, Lydia Guadalupe NO ESPECIFICADO NO ESPECIFICADO Tamez Guerra, Reyes Silvestre NO ESPECIFICADO NO ESPECIFICADO Rodríguez Padilla, Cristina NO ESPECIFICADO NO ESPECIFICADO
Fecha del depósito:	13 Jul 2022 20:21
Última modificación:	23 Ene 2023 19:46
URI:	http://eprints.uanl.mx/id/eprint/23570

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