Real-world practice of acute leukemia intrathecal chemotherapy administration: a mexican nationwide survey

Colunga Pedraza, Julia Esther y Colunga Pedraza, Perla Rocío y Benavides López, Hilda Valeria y Mares Gil, José Eduardo y Jiménez Antolínez, Yajaira Valentine y Mancías Guerra, Consuelo y Velasco Ruiz, Ileana Yazmín y González Llano, Óscar (2021) Real-world practice of acute leukemia intrathecal chemotherapy administration: a mexican nationwide survey. Hematology, Transfusion and Cell Therapy, 45 (2). S25-S29. ISSN 2531-1379

Vista previa

Texto
27710.pdf - Versión Publicada
Available under License Creative Commons Attribution Non-commercial No Derivatives.
Download (284kB) | Vista previa

URL o página oficial: https://www.sciencedirect.com/science/article/pii/...

Resumen

Introduction: Intrathecal chemotherapy is a mainstay component of acute lymphoblastic leukemia treatment. In Mexico, there is a considerable practice variability in aspects, such as the manner of preparation and the administration technique. Objective: Our objective was to describe the different techniques used for the application of ITC and review the existing recommendations in the literature. Method: A cross-sectional, nationwide survey study was conducted by an electronic questionnaire sent to hematologists and oncologists in Mexico. We collected demographic data, personal experience, intrathecal chemotherapy techniques, drug preparation and postprocedural conduct. Results: We received 173 responses. Twenty percent had an anesthesiologist administering sedation and pain management. The platelet count considered safe was 50 £ 109 /L in 48% of the participants. In 77% (n = 133) of the cases, the conventional needle with stylet used was, 49% did not receive any added diluent in the intrathecal chemotherapy and only 42% were recommended to rest in a horizontal position for more than 30 min. Conclusion: We identified a considerable variation in the administration of intrathecal chemotherapy across the hematologists in Mexico. We discuss the implications and opportunities in reducing the variation in our setting, highlighting the unmet need to establish guidelines that should be evaluated by the Mexican professional society to produce a position paper regarding practice standardization.

Tipo de elemento:

Article

Palabras claves no controlados:

Práctica del mundo real; Quimioterapia intratecal; Leucemia.

Materias:

R Medicina > RC Medicina Interna, Psiquiatría, Neurología

Divisiones:

Medicina

Usuario depositante:

Editor Repositorio

Creadores:

Creador	Email	ORCID
Colunga Pedraza, Julia Esther	drajuliaesther@gmail.com	orcid.org/0000-0001-7933-094X
Colunga Pedraza, Perla Rocío	NO ESPECIFICADO	orcid.org/0000-0002-9937-439X
Benavides López, Hilda Valeria	NO ESPECIFICADO	orcid.org/0000-0001-8290-0480
Mares Gil, José Eduardo	eres.fnix@gmail.com	orcid.org/0000-0002-8964-0228
Jiménez Antolínez, Yajaira Valentine	valejmza@gmail.com	orcid.org/0000-0002-7988-8094
Mancías Guerra, Consuelo	consuelo@mancias.com	orcid.org/0000-0003-4292-8635
Velasco Ruiz, Ileana Yazmín	NO ESPECIFICADO	orcid.org/0000-0002-2026-1502
González Llano, Óscar	NO ESPECIFICADO	NO ESPECIFICADO