In Vitro Antiprotozoal Activity of Schinus molle Extract, Partitions, and Fractions against Trypanosoma cruzi

Rodríguez Garza, Nancy Edith y Quintanilla Licea, Ramiro y Gomez Flores, Ricardo y Galaviz Silva, Lucio y Molina Garza, Zinnia Judith (2024) In Vitro Antiprotozoal Activity of Schinus molle Extract, Partitions, and Fractions against Trypanosoma cruzi. Plants, 13. pp. 1-11. ISSN 2223-7747

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URL o página oficial: https://www.mdpi.com/2223-7747/13/16/2177

Resumen

Chagas disease, caused by the protozoan Trypanosoma cruzi, represents an important and worldwide public health issue, particularly in Latin America. Limitations of conventional treatment with benznidazole and nifurtimox underscore the urgent need for new therapeutic strategies for this disease. Schinus molle, a tree used in traditional medicine for various ailments, has demonstrated promising antiparasitic activity. The in vitro anti-T. cruzi activity of Schinus molle crude methanol extract, partitions, and fractions, as well as their cytotoxicity in Vero cells and Artemia salina, and hemolytic activity in human erythrocytes were assessed. Most of the extracts possessed anti-T. cruzi effects, with Sm-CF3 being the fraction with the highest activity (IC50 = 19 μg/mL; SI = 6.8). Gas chromatography–mass spectrometry analysis identified 20 compounds, with fatty acyls comprising the predominant chemical class (55%). We also identified the antiparasitic compounds cis-5,8,11,14,17- eicosapentaenoic acid and trans-Z-α-bisabolene epoxide, suggesting their potential contribution to the observed anti-T. cruzi activity. In conclusion, our findings support the therapeutic potential of S. molle as a source of novel antiparasitic agents against T. cruzi.

Tipo de elemento:

Article

Palabras claves no controlados:

Trypanosoma cruzi; Enfermedad de Chagas; Schinus molle; Actividad antiparasitaria; Plantas medicinales; Salud pública.

Materias:

CONACYT > Biología y Química

Divisiones:

Ciencias Biológicas

Usuario depositante:

MC Nancy Edith Rodríguez Garza

Creadores:

Creador	Email	ORCID
Rodríguez Garza, Nancy Edith	nancy.rodriguezgrz@uanl.edu.mx	orcid.org/0000-0003-3201-5437
Quintanilla Licea, Ramiro	rquintanilla.uanl@gmail.com	NO ESPECIFICADO
Gomez Flores, Ricardo	rgomez60@hotmail.com	orcid.org/0000-0002-9518-4433
Galaviz Silva, Lucio	lucio.galavizsl@uanl.edu.mx	NO ESPECIFICADO
Molina Garza, Zinnia Judith	molinazinnia@hotmail.com	NO ESPECIFICADO