Is the Cis-Element CACCC-Box a Master Regulatory Element during Cardiovascular Disease? A Bioinformatics Approach from the Perspective of the Krüppel-like Family of Transcription Factors

García Loredo, Juan Andrés y Santoyo Suarez, Michelle G. y Rodríguez Núñez, Oscar y Benitez Chao, Diego Francisco y Garza Treviño, Elsa N. y Zapata Morin, Patricio Adrián y Padilla Rivas, Gerardo R. y Islas, Jose Francisco (2024) Is the Cis-Element CACCC-Box a Master Regulatory Element during Cardiovascular Disease? A Bioinformatics Approach from the Perspective of the Krüppel-like Family of Transcription Factors. Life, 14 (4). p. 493. ISSN 2075-1729

Vista previa

Texto
27920.pdf - Versión Publicada
Available under License Creative Commons Attribution.
Download (2MB) | Vista previa

URL o página oficial: http://doi.org/10.3390/life14040493

Resumen

The CACCC-box motif emerges as a pivotal cis-regulatory element implicated in diverse developmental processes and diseases, particularly cardiovascular diseases (CVDs). This study centers on the intricate interplay between the CACCC-box and its binding proteins such as: the Krüppel-Like Family (KLF) of transcription factors as primary effectors in the context of CVDs. Our analysis was through a bioinformatics approach, which revealed significant transcriptional activity among KLF subgroup 2, exhibiting the highest number of interactions focusing on the established roles: pluripotency, cancer, and cardiovascular development and diseases. Our analysis reveals KLF’s interactions with GATA4, MEF2C, NKX2.5 and other ~90 potential genes that participate in the regulation of the hypertrophic environment (or CVDs’ Environment). Also, the GO analysis showed that genes containing the motif CACCC were enriched for multiple CVDs; in combination with STRING analysis, these results pointed to a link between KLFs and these diseases. The analysis further identifies other potential CACCC-box binding factors, such as SP family members, WT1, VEZF1, and -SALL4, which are implicated in cardiac contraction, remodeling, and inflammation processes.

Tipo de elemento:

Article

Palabras claves no controlados:

Krüppel-like factor, Transcription factors, CVDs, CACCC-box, diabetes, SP1

Materias:

Q Ciencia > QP Fisiología

Divisiones:

Medicina

Usuario depositante:

Editor Repositorio

Creadores:

Creador	Email	ORCID
García Loredo, Juan Andrés	andres.garcialrd@uanl.edu.mx	NO ESPECIFICADO
Santoyo Suarez, Michelle G.	s.antoyo@hotmail.es	NO ESPECIFICADO
Rodríguez Núñez, Oscar	oscar.rodrigueznu@uanl.edu.mx	NO ESPECIFICADO
Benitez Chao, Diego Francisco	diego.benitezch@uanl.edu.mx	NO ESPECIFICADO
Garza Treviño, Elsa N.	elsa.garzatr@uanl.edu.mx	orcid.org/0000-0002-1042-4603
Zapata Morin, Patricio Adrián	patricio.zapatamor@uanl.edu.mx	orcid.org/0000-0003-1851-2293
Padilla Rivas, Gerardo R.	gerardo.padillarv@uanl.edu.mx	NO ESPECIFICADO
Islas, Jose Francisco	jislas.me0117@uanl.edu.mx	orcid.org/0000-0002-0337-9912