Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways

Arredondo Mendoza, Gerardo I. y Jiménez Salas, Zacarías y Guzmán de la Garza, Francisco Javier y Solís Pérez, Elizabeth y López Cabanillas Lomelí, Manuel y González Martínez, Blanca Edelia y Campos Góngora, Eduardo (2020) Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways. Molecules, 25 (17). pp. 3875-3886. ISSN 1420-3049

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URL o página oficial: http://doi.org/10.3390/molecules25173875

Resumen

Hypertension (HT) is considered to be a potential risk factor for cardiovascular diseases and has been directly related to pathologies such as obesity and dyslipidemias. Angiotensin-converting enzyme inhibitors (ACEIs) blocked the renin-angiotensin-aldosterone cascade diminishing the production of angiotensin II and the level of bradykinin, produced by the kallikrein-kinin system. Although ACEIs are effective therapeutics in regulating HT, they present several side-effects that can be due to their mechanism of action (as hypotension, cough, dizziness, light-headedness or hyperkalemia) to specific drug molecular structure (skin rash, neutropenia and tasting disorders) or due to associated pathologies in the patients (it has been considered a possible nephrotoxic effect when ACEIs are administered in combination with angiotensin receptor blockers, in patients that present comorbidities as diabetes, acute kidney injury or chronic kidney disease). Therefore, it is necessary the searching for new products with ACEI activity that do not produce side effects. Interestingly, species of the plant genus Salvia have been found to possess hypotensive effects. In the present study, we analyzed the effects of the ethanolic extract of Salvia hispanica L. seeds (EESH) on the expression of genes involved in pathways regulating HT. Administration of EESH to hypertensive rats inhibited the angiotensin-converting enzyme (ACE) activity along with a decrease in Ace and elevation of Agtr1a and Nos3 gene expression, as compared to that in healthy rats. Moreover, these results were similar to those observed with captopril, an antihypertensive drug used as a control. No significant change in the expression of Bdkrb2 gene was observed in the different groups of rats. To conclude, our results demonstrate that EESH regulates blood pressure (BP) in hypertensive rats through transcriptionally regulating the expression of genes that participate in different pathways involving ACE.

Tipo de elemento:

Article

Palabras claves no controlados:

Salvia hispanica L. extract, Bioactive compounds, Hypertension; Gene expression; Rats

Materias:

R Medicina > RC Medicina Interna, Psiquiatría, Neurología

Divisiones:

Medicina

Usuario depositante:

Editor Repositorio

Creadores:

Creador	Email	ORCID
Arredondo Mendoza, Gerardo I.	gerardo.arredondom@uanl.mx	NO ESPECIFICADO
Jiménez Salas, Zacarías	zacarias.jimenezs@uanl.mx	NO ESPECIFICADO
Guzmán de la Garza, Francisco Javier	fcojguzman@hotmail.com	orcid.org/0000-0001-7925-6524
Solís Pérez, Elizabeth	elizabeth.solis@uanl.mx	orcid.org/0000-0002-3702-3607
López Cabanillas Lomelí, Manuel	manuel.lopezc@uanl.mx	NO ESPECIFICADO
González Martínez, Blanca Edelia	blanca.gonzalezma@uanl.mx	NO ESPECIFICADO
Campos Góngora, Eduardo	eduardo.camposg@uanl.mx	NO ESPECIFICADO