Metastatic triple-negative breast cancer successfully treated with bicalutamide

Salazar Mejía, Carlos Eduardo y García Gutierrez, María Elena y Rodríguez Alvarez, Carlos Javier y Flores Caballero, Miguel Angel y Wimer Castillo, Blanca Otilia y Vidal Gutiérrez, Oscar (2020) Metastatic triple-negative breast cancer successfully treated with bicalutamide. Pan African Medical Journal, 37. p. 324. ISSN 1937-8688

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Resumen

Triple-negative breast cancer (TNBC) is considered the group with the worst prognosis among the four molecular subtypes of breast cancer. The current treatment of metastatic TNBC is traditionally limited to chemotherapy. Androgenic receptors (AR) are an emerging target with therapeutic potential in TNBC refractory to chemotherapy. We present the case of a 66-year-old woman diagnosed with TNBC who had failed to 2 lines of chemotherapy after a diagnosis of recurrence. Immunohistochemistry was requested for the determination of AR, which was positive without specifying the percentage of AR expression. We started bicalutamide 50 mg QD, achieving disease control. At 50 months from the start of this treatment, the patient remains in stable disease, without any toxicity associated with treatment. Androgenic blockade could represent another management option for patients with advanced TNBC. The drug of choice and the dose to be used in this setting remains controversial. Furthermore, there is no consensus on the percentage of tumoral expression of AR to be considered a candidate for this treatment.

Tipo de elemento:

Article

Palabras claves no controlados:

Breast cancer, Bicalutamide, Androgen therapy, Case report

Divisiones:

Medicina

Usuario depositante:

Editor Repositorio

Creadores:

Creador	Email	ORCID
Salazar Mejía, Carlos Eduardo	carlos.salazarmj@uanl.edu.mx	orcid.org/0000-0002-6413-0571
García Gutierrez, María Elena	NO ESPECIFICADO	NO ESPECIFICADO
Rodríguez Alvarez, Carlos Javier	NO ESPECIFICADO	NO ESPECIFICADO
Flores Caballero, Miguel Angel	NO ESPECIFICADO	NO ESPECIFICADO
Wimer Castillo, Blanca Otilia	NO ESPECIFICADO	NO ESPECIFICADO
Vidal Gutiérrez, Oscar	NO ESPECIFICADO	NO ESPECIFICADO