High prevalence of diabetic retinopathy and lack of association with integrin alpha2 gene polymorphisms in patients with type 2 diabetes from Northeastern Mexico

Cepeda Nieto, Ana Cecilia y Esquivel Contreras, María Teresa y Durán Iñiguez, Francisco y Salinas Santander, Mauricio Andrés y Gallardo Blanco, Hugo Leonid y Esparza González, Sandra Cecilia y Zugasti Cruz, Alejandro y Morlett Chávez, Jesús Antonio y Córdova Alvelais, Luis Tlaloc (2015) High prevalence of diabetic retinopathy and lack of association with integrin alpha2 gene polymorphisms in patients with type 2 diabetes from Northeastern Mexico. Experimental and Therapeutic Medicine, 10 (2). pp. 435-444. ISSN 1792-0981, 1792-1015

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Resumen

Diabetic retinopathy (DR) is one of the primary causes of blindness in the working age population and is characterized by angiogenesis in the retina. Platelets have been suggested to be involved in the pathogenesis of diabetic microvascular complications. The integrin receptor for collagen/laminin, α2β1, mediates platelet primary adhesion to subendothelial tissues, which is an essential first step in thrombus formation. The gene encoding the α2 subunit of α2β1 integrin has ≥8 polymorphisms, including a BglII/NdeI restriction fragment length polymorphism. To explore the prevalence of DR in a population from Northeastern Mexico, unrelated, hospitalized patients who had received a diagnosis of type 2 diabetes mellitus (DM2) at least 10 years previ‑ ously were recruited (n=177). DR was diagnosed in a masked manner by independent ophthalmologists using fundus images captured using a non‑mydriatic retinal camera

Tipo de elemento:

Article

Palabras claves no controlados:

Mexican population, Diabetic Retinopathy, Polymorphism, Alpha2 integrin gene

Materias:

CONACYT > Biología y Química
CONACYT > Medicina y Ciencias de la Salud

Divisiones:

Medicina

Usuario depositante:

Dr.C. Hugo Gallardo Blanco

Creadores:

Creador	Email	ORCID
Cepeda Nieto, Ana Cecilia	NO ESPECIFICADO	NO ESPECIFICADO
Esquivel Contreras, María Teresa	NO ESPECIFICADO	NO ESPECIFICADO
Durán Iñiguez, Francisco	NO ESPECIFICADO	NO ESPECIFICADO
Salinas Santander, Mauricio Andrés	NO ESPECIFICADO	NO ESPECIFICADO
Gallardo Blanco, Hugo Leonid	hugo.gallardobl@uanl.edu.mx	orcid.org/0000-0002-7816-4967
Esparza González, Sandra Cecilia	NO ESPECIFICADO	NO ESPECIFICADO
Zugasti Cruz, Alejandro	NO ESPECIFICADO	NO ESPECIFICADO
Morlett Chávez, Jesús Antonio	NO ESPECIFICADO	NO ESPECIFICADO
Córdova Alvelais, Luis Tlaloc	NO ESPECIFICADO	NO ESPECIFICADO