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Genetic variants in {KCNJ}11, {TCF}7L2 and {HNF}4A are associated with type 2 diabetes, {BMI} and dyslipidemia in families of Northeastern Mexico: A pilot study
Gallardo Blanco, Hugo Leonid y Villarreal Pérez, Jesús Zacarías y Cerda Flores, Ricardo Martín y Figueroa, Andrés y Sánchez Domínguez, Celia Nohemí y Gutiérrez Valverde, Juana Mercedes y Torres Muñoz, Iris Carmen y Lavalle González, Fernando Javier y Gallegos Cabriales, Esther Carlota y Martínez Garza, Laura Elia (2017) Genetic variants in {KCNJ}11, {TCF}7L2 and {HNF}4A are associated with type 2 diabetes, {BMI} and dyslipidemia in families of Northeastern Mexico: A pilot study. Experimental and Therapeutic Medicine, 13 (2). pp. 523-529. ISSN 1792-0981, 1792-1015
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Texto
Gallardo-Blanco et al. - 2017 - Genetic variants in KCNJ11, TCF7L2 and HNF4A are a.pdf - Versión Publicada Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (693kB) | Vista previa |
Resumen
The aim of the present study was to investigatewhether genetic markers considered risk factors for metabolic syndromes, including dyslipidemia, obesity and type 2 diabetes mellitus (T2DM), can be applied to a Northeastern Mexican population. A total of 37 families were analyzed for 63 single nucleotide polymorphisms (SNPs), and the age, body mass index (BMI), glucose tolerance values and blood lipid levels, including those of cholesterol, low-density lipoprotein (LDL), very LDL (VLDL), high-density lipoprotein (HDL) and triglycerides were evaluated. Three genetic markers previously associated with metabolic syndromes were identified in the sample popula-tion, including KCNJ11, TCF7L2 and HNF4A. The KCNJ11SNP rs5210 was associated with T2DM, the TCF7L2 SNP rs11196175 was associated with BMI and cholesterol and LDL levels, the TCF7L2 SNP rs12255372 was associated with BMI and HDL, VLDL and triglyceride levels, and the HNF4A SNP rs1885088 was ssociated with LDL levels (P<0.05).
| Tipo de elemento: | Article | |||||||||||||||||||||||||||||||||
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| Palabras claves no controlados: | HNF4A, KCNJ11, TCF7L2, Association, Body mass index, Cholesterol, High-density lipoprotein, Linkage disequilibrium, Low-density lipoprotein, Type 2 diabetes | |||||||||||||||||||||||||||||||||
| Materias: | CONACYT > Biología y Química CONACYT > Medicina y Ciencias de la Salud |
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| Divisiones: | Medicina | |||||||||||||||||||||||||||||||||
| Usuario depositante: | Dr.C. Hugo Gallardo Blanco | |||||||||||||||||||||||||||||||||
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| Fecha del depósito: | 03 Sep 2026 16:05 | |||||||||||||||||||||||||||||||||
| Última modificación: | 03 Sep 2026 16:05 | |||||||||||||||||||||||||||||||||
| URI: | http://eprints.uanl.mx/id/eprint/31440 |
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