{pH}-Sensitive Chitosan-Based Hydrogels Trap Poloxamer Micelles as a Dual-Encapsulating Responsive System for the Loading and Delivery of Curcumin

Herrera Alonso, Alejandra E. y Rodríguez Chávez, Daniela F. y Toxqui Terán, Alberto y Rubio Valle, José F. y Martin Alfonso, José E. y Longoria García, Samuel y Gallardo Blanco, Hugo L. y Sánchez Domínguez, Celia N. y Sánchez Domínguez, Margarita (2025) {pH}-Sensitive Chitosan-Based Hydrogels Trap Poloxamer Micelles as a Dual-Encapsulating Responsive System for the Loading and Delivery of Curcumin. Polymers, 17 (10). pp. 1-24. ISSN 2073-4360

Vista previa

Texto
31457.pdf - Versión Aceptada
Available under License Creative Commons Attribution Non-commercial No Derivatives.
Download (11MB) | Vista previa

URL o página oficial: https://www.mdpi.com/2073-4360/17/10/1335

Resumen

{pH}-sensitive hydrogels are important soft biomaterials as they mimic biological organisms by altering their properties in response to small {pH} changes in biological fluids. In this work, novel chitosan (Cs) hydrogels were developed using an innovative dual curcumin (Cur) encapsulation system. Cur was loaded into poloxamer 407 micelles and incorporated into citric acid ({CA}) cross-linked Cs hydrogels using a central composite design. The hydrogels were characterized using Fourier transform infrared spectroscopy ({FTIR}), scanning electron microscopy ({SEM}), differential scanning calorimetry ({DSC}), rheological tests, and in vitro experiments, such as hemolysis and cytotoxicity assays. {FTIR} confirmed cross-linking between Cs and {CA}, while {DSC} suggested interactions between Cur-loaded micelles and the hydrogel matrix. Rheological analysis revealed gel-like behavior, with G' consistently higher than G, and temperature influenced hydrogel properties. {SEM} showed a denser network when Cur-loaded micelles were incorporated, slowing Cur release. At physiological {pH} (7.4), 75\% of Cur was released after 7 days, while 84\% was released at {pH} 5.5, showing {pH}-responsive behavior. Cytotoxicity tests showed over 80\% viability of {VERO} {CCL}-81 cells (0.2-20 ppm hydrogel). This dual-encapsulation system provides a simple and effective platform for loading lipophilic drugs into {pH}-responsive hydrogels.

Tipo de elemento:

Article

Palabras claves no controlados:

Curcumina; Hidrogel; Hidrogel sensible al pH; Micela de poloxámero; Reología

Materias:

R Medicina > R Medicina en General

Divisiones:

Medicina

Usuario depositante:

Dr.C. Hugo Gallardo Blanco

Creadores:

Creador	Email	ORCID
Herrera Alonso, Alejandra E.	alejandra.herrera@cimav.edu.mx	orcid.org/0000-0003-2009-1512
Rodríguez Chávez, Daniela F.	daniela.rodriguez@cimav.edu.mx	orcid.org/0009-0001-9679-0582
Toxqui Terán, Alberto	NO ESPECIFICADO	orcid.org/0000-0001-9897-5655
Rubio Valle, José F.	josefernando.rubio@diq.uhu.es	orcid.org/0000-0001-9940-9807
Martin Alfonso, José E.	NO ESPECIFICADO	orcid.org/0000-0003-3180-7838
Longoria García, Samuel	samuel.longoriagr@uanl.edu.mx	orcid.org/0000-0002-4056-5343
Gallardo Blanco, Hugo L.	hugo.gallardobl@uanl.edu.mx	orcid.org/0000-0002-7816-4967
Sánchez Domínguez, Celia N.	celia.sanchezdm@uanl.edu.mx	orcid.org/0000-0002-3444-9565
Sánchez Domínguez, Margarita	margarita.sanchez@cimav.edu.mx	orcid.org/0000-0003-4755-4441