Biological Activities of Extracts from Aerial Parts of Salvia pachyphylla Epling Ex Munz

Almada Taylor, Gabriela y Díaz Rubio, Laura y Salazar Aranda, Ricardo y Waksman de Torres, Noemí y Uranga Solis, Carla y Delgadillo Rodríguez, José y Ramos, Marco y Padrón, José y Hernández Martínez, Rufina y Córdova Guerrero, Iván (2018) Biological Activities of Extracts from Aerial Parts of Salvia pachyphylla Epling Ex Munz. Plants, 7 (4). pp. 1-13. ISSN 2223-7747

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Resumen

Abstract: The antioxidant, antimicrobial, antiproliferative, and enzyme inhibitory properties of five extracts from aerial parts of Salvia pachyphylla Epling ex Munz were examined to assess the prospective of this plant as a source of natural products with therapeutic potential. These properties were analyzed by performing a set of standard assays. The extract obtained with dichloromethane showed the most variety of components, as they yielded promising results in all completed assays. Furthermore,theextractobtainedwithethylacetateexhibitedthegreatestantioxidantactivity,aswell as the best xanthine oxidase inhibitory activity. Remarkably, both extracts obtained with n-hexane or dichloromethane revealed significant antimicrobial activity against the Gram-positive bacteria; additionally, they showed greater antiproliferative activity against three representative cell lines of the most common types of cancers in women worldwide, and against a cell line that exemplifies cancers that typically develop drug resistance. Despite that, other extracts were less active, such as the methanolic or aqueous; their results are promising for the isolation and identification of novel bioactive molecules.

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