Bactericide, Antioxidant and Cytotoxic Activities from Marine Algae of Genus Laurencia Collected in Baja California Sur, Mexico

García Davis, Sara y Murillo Álvarez, Iván y Muñoz Ochoa, Mauricio y Carranza Torres, Edith y Garza Padrón, Ruth Amelia y Morales Rubio, María Eufemia y Viveros Valdez, José Ezequiel (2018) Bactericide, Antioxidant and Cytotoxic Activities from Marine Algae of Genus Laurencia Collected in Baja California Sur, Mexico. International Journal of Pharmacology, 14 (3). pp. 391-396. ISSN 18117775

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URL o página oficial: http://doi.org/10.3923/ijp.2018.391.396

Resumen

Abstract Background and Objective: Marine environment represents countless and diverse resource for new drugs to combat major diseases. Extracts from four Laurencia species ( L. johnstonii, L. pacifica, L. gardneri and L. papillosa) from Baja California Sur, México were evaluated for their antioxidant, antibacterial and cytotoxic activity. Methodology: The antioxidants activity of Laurencia sp. were evaluated using the radical scavenging activity in three in vitro radicals: 1,1-Diphenyl-2-picrylhydrazyl (DPPH), 2,2'-Azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) and nitric oxide (NO). The antibacterial activity was evaluated by the broth microdilution method to determinate the Minimum Inhibitory Concentrations (MIC) against Staphylococcus aureus, Bacillus subtilis, Enterococcus faecalis, Micrococcus luteus, Pseudomonas aerugi nosa and Klebsiella pneumoniae . The cytotoxicity was analyzed on HeLa (cervix adenocarcinoma) and Vero (kidney epithelial) cells, using the reduction of tetrazolium salt WST-1. Results: The seaweed of genus Laurencia demonstrated an overall low activity, with half maximal effective concentration (EC50) values >1.5 mg mLG1. Laurencia pacifica showed the best biocide effects with MIC of 6.25 µg mLG1 against Gram positive bacterial and cytotoxic potential with half inhibitory concentration (IC50) <30 µg mLG1 against Vero and HeLa cells. Conclusion: Some Laurencia species have a great antibacterial and cytotoxic activity which could be considered for future studies.

Tipo de elemento:

Article

Materias:

Q Ciencia > QD Química
R Medicina > RM Terapéutica, Farmacología

Divisiones:

Ciencias Biológicas

Usuario depositante:

Lic. Josimar Pulido

Creadores:

Creador	Email	ORCID
García Davis, Sara	NO ESPECIFICADO	NO ESPECIFICADO
Murillo Álvarez, Iván	NO ESPECIFICADO	NO ESPECIFICADO
Muñoz Ochoa, Mauricio	NO ESPECIFICADO	NO ESPECIFICADO
Carranza Torres, Edith	NO ESPECIFICADO	NO ESPECIFICADO
Garza Padrón, Ruth Amelia	NO ESPECIFICADO	NO ESPECIFICADO
Morales Rubio, María Eufemia	NO ESPECIFICADO	NO ESPECIFICADO
Viveros Valdez, José Ezequiel	jose.viverosvld@uanl.edu.mx	orcid.org/0000-0001-5944-7972