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Cumulative antitumor effect of bismuth lipophilic nanoparticles and cetylpyridinium chloride in inhibiting the growth of lung cancer
García Cuellar, Claudia María y Hernández Delgadillo, René y Torres Betancourt, Jesús Alejandro y Solís Soto, Juan Manuel y Meester, Irene y Sánchez Pérez, Yesennia y Pineda Aguilar, Nayely y Nakagoshi Cepeda, Sergio Eduardo y Sánchez Nájera, Rosa Isela y Nakagoshi Cepeda, María Argelia Akemi y Chellam, Shankararaman y Cabral Romero, Claudio (2023) Cumulative antitumor effect of bismuth lipophilic nanoparticles and cetylpyridinium chloride in inhibiting the growth of lung cancer. Journal of Applied Biomaterials & Functional Materials, 21. pp. 1-10. ISSN 2280-8000
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Texto
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Resumen
Objective: To determine the combined antitumor effect of bismuth lipophilic nanoparticles (BisBAL NP) and cetylpyridinium chloride (CPC) on human lung tumor cells. Material and methods: The human lung tumor cells A549 were exposed to 1–100 µM BisBAL NP or CPC, either separately or in a 1:1 combination. Cell viability was measured with the PrestoBlue assay, the LIVE/DEAD assay, and fluorescence microscopy. The integrity and morphology of cellular microtubules were analyzed by immunofluorescence. Results: A 24-h exposure to 1 µM solutions reduced A549 growth with 21.5% for BisBAL NP, 70.5% for CPC, and 92.4% for the combination ( p < 0.0001), while a 50 µM BisBAL NP/CPC mixture inhibited cell growth with 99% ( p < 0.0001). BisBAL NP-curcumin conjugates were internalized within 30 min of exposure and could be traced within the nucleus of tumor cells within 2 h. BisBAL NP, but not CPC, interfered with microtubule organization, thus interrupting cell replication, similar to the action mechanism of docetaxel. Conclusion: The growth inhibition of A549 human tumor cells by BisBAL NP and CPC was cumulative as of 1 µM. The BisBAL NP/CPC combination may constitute an innovative and cost-effective alternative for treating human lung cancer.
| Tipo de elemento: | Article | |||||||||||||||||||||||||||||||||||||||
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| Palabras claves no controlados: | Efecto antitumoral acumulativo; Nanopartículas lipofílicas de bismuto; Cloruro de cetilpiridinio; Cáncer de pulmón humano; Quimioterapia; Ensayos de captación | |||||||||||||||||||||||||||||||||||||||
| Materias: | T Tecnología > TP Tecnología Química | |||||||||||||||||||||||||||||||||||||||
| Divisiones: | Medicina | |||||||||||||||||||||||||||||||||||||||
| Usuario depositante: | Editor Repositorio | |||||||||||||||||||||||||||||||||||||||
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| Fecha del depósito: | 28 Jun 2023 19:13 | |||||||||||||||||||||||||||||||||||||||
| Última modificación: | 28 Jun 2023 19:13 | |||||||||||||||||||||||||||||||||||||||
| URI: | http://eprints.uanl.mx/id/eprint/25650 |
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